[Ovarian carcinoma. Do the subtypes reflect different diseases?].

Der Pathologe
Martin Köbel

Abstract

Lack of therapeutic options and poor reproducibility of histopathological subtypes have been the reasons that ovarian carcinomas are currently treated as monolithic entity. Histopathological grading is used to identify those patients who can be spared adjuvant therapy. With slight modifications of the WHO based subtype classification we have shown that subtypes (i.e. serous, endometrioid, clear cell, mucinous) can be reproducibly used to stratify patients according to disease-specific survival. As these pathologically identifiable subtypes have different epidemiologic and genetic risk factors, precursor lesions, molecular abnormalities and clinical behaviour, screening and management strategies have to be subtype-specific.

References

Apr 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B LundJ Olsen
Apr 27, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M ShimizuS Fujii
Feb 13, 2001·Gynecologic Oncology·E S HoF S Liu
Sep 28, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·P A ShawI J Jacobs
Apr 17, 2004·The American Journal of Surgical Pathology·John H Eichhorn, Robert H Young
Apr 28, 2004·The American Journal of Pathology·Ie-Ming Shih, Robert J Kurman
Mar 24, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Martin KöbelSteffen Hauptmann
Aug 2, 2007·The American Journal of Surgical Pathology·Anais MalpicaElvio G Silva
Nov 8, 2007·PloS One·Marianne TuefferdSophie Camilleri-Broët
Jan 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Frank BartelSteffen Hauptmann
Feb 1, 2008·Gynecologic Oncology·Caroline A BartonPhilippa M O'Brien
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wilko WeichertCarsten Denkert
Jul 8, 2008·Human Pathology·C Blake GilksUNKNOWN Cheryl Brown Ovarian Cancer Outcomes Unit of the British Columbia Cancer Agency
Aug 21, 2008·Neoplasia : an International Journal for Oncology Research·Wilko WeichertMartin Köbel
Oct 3, 2008·The American Journal of Surgical Pathology·Martin KöbelC Blake Gilks

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