PMID: 18709705Aug 19, 2008Paper

Ovarian dysfunction and the premenopausal origins of coronary heart disease

Menopause : the Journal of the North American Menopause Society
J R Kaplan, S B Manuck

Abstract

The menopausal loss of cyclic ovarian function is believed to contribute to coronary heart disease (CHD). However, ovarian function varies substantially throughout the premenopausal years, with disruptions in hormonal activity ranging from mild to profound. Here we propose our "precocious acceleration" hypothesis, which holds that to the extent cyclic ovarian function affords protection against CHD, even mild ovulatory abnormalities in young women will accelerate development of this disease. Data relating to the expression and incidence of premenopausal ovarian dysfunction in women and its relationship to CHD are reviewed. Also reviewed are the results from experiments conducted with socially housed cynomolgus monkeys (Macaca fascicularis), focused on the causes, occurrence, and pathobiological sequelae of premenopausal ovarian dysfunction. The implications of the foregoing material for understanding the health of peri- and postmenopausal women are then considered. Epidemiological and clinical studies indicate that common premenopausal reproductive abnormalities (manifested along a continuum from mild subclinical alterations to complete suppression) are associated with increased risk of CHD. This increased risk is probably medi...Continue Reading

References

Aug 1, 1978·Annals of Internal Medicine·T GordonP M McNamara
Nov 1, 1990·American Journal of Obstetrics and Gynecology·J H Liu
Jan 1, 1990·Annals of the New York Academy of Sciences·M J StampferW C Willett
Nov 1, 1990·The New England Journal of Medicine·J C PriorA E Burgess
Nov 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M R AdamsT B Clarkson
Sep 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M G Hull
Jul 1, 1988·Fertility and Sterility·M J McNeely, M R Soules
Sep 1, 1986·American Journal of Obstetrics and Gynecology·R H ReindollarP G McDonough
Apr 30, 1987·The New England Journal of Medicine·G A ColditzC H Hennekens
Nov 1, 1987·American Journal of Obstetrics and Gynecology·C La VecchiaF Parazzini
Mar 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M R AdamsD R Koritnik
Dec 1, 1984·Atherosclerosis·J R KaplanD R Koritnik
Jan 1, 1981·American Journal of Obstetrics and Gynecology·L RosenbergF E Speizer
Dec 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·J R KaplanT B Clarkson
Jul 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·J K WilliamsT B Clarkson
Mar 1, 1994·Journal of Public Health Medicine·D J Gunnell, P Ewings
Feb 1, 1996·The Journal of Clinical Endocrinology and Metabolism·M P Warren
Jul 14, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M SowersM Jannausch
Nov 14, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·E O TalbottL H Kuller
Feb 13, 2001·Annual Review of Medicine·A Dunaif, A Thomas
Feb 12, 2002·American Journal of Epidemiology·Miriam J J de KleijnYolanda van der Graaf
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Caren G SolomonJoann E Manson
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Oct 2, 2002·Obstetrics and Gynecology Clinics of North America·Janice D WagnerRonald T Burkman
Oct 19, 2002·Maturitas·Sophia C JansenEvert G Schouten
Feb 11, 2003·Journal of the American College of Cardiology·C Noel Bairey MerzUNKNOWN WISE Study Group
May 15, 2003·American Journal of Epidemiology·Bjarne K JacobsenGunnar Kvåle
Aug 9, 2003·The New England Journal of Medicine·Howard N HodisUNKNOWN Women's Estrogen-Progestin Lipid-Lowering Hormone Atherosclerosis Regression Trial Research Group
Oct 1, 2003·Trends in Endocrinology and Metabolism : TEM·Susan Sam, Andrea Dunaif
Apr 28, 2004·ILAR Journal·Jay R Kaplan, Stephen B Manuck
Apr 28, 2004·ILAR Journal·David H AbbottDaniel A Dumesic
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Ricardo AzzizBulent O Yildiz
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Sophia N KalantaridouLampros K Michalis
Dec 17, 1949·Journal of the American Medical Association·G E S JONES
Nov 16, 2004·Endocrine·S Mitchell HarmanFrederick Naftolin
Nov 20, 2004·Obstetrics and Gynecology Clinics of North America·Orhan Bukulmez, Aydin Arici
Jul 9, 2005·The Journal of Endocrinology·Robert T ChattertonMonica Morrow

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Citations

Jul 7, 2012·Human Reproduction·M E BleilM I Cedars
May 30, 2013·Menopause : the Journal of the North American Menopause Society·Maria E BleilMarcelle I Cedars
Sep 4, 2012·Hormones and Behavior·Vasiliki MichopoulosDonna Toufexis
Jan 17, 2012·Psychoneuroendocrinology·Vasiliki MichopoulosMark E Wilson
Jan 27, 2015·Current Atherosclerosis Reports·Chrisandra ShufeltC Noel Bairey Merz
Aug 9, 2016·Neuroscience and Biobehavioral Reviews·Viola Vaccarino, J Douglas Bremner
Oct 16, 2016·The American Journal of Cardiology·Elena Salmoirago-BlotcherIlan S Wittstein
Apr 4, 2017·The Journal of Clinical Endocrinology and Metabolism·Catherine M GordonMichelle P Warren
Mar 16, 2018·Climacteric : the Journal of the International Menopause Society·S Witkowski, C Serviente
Mar 18, 2017·Nature Reviews. Endocrinology·Eugenia MorselliDeborah J Clegg
Oct 12, 2018·Physiology·Walter A RoccaVirginia M Miller
Aug 28, 2020·Therapeutic Advances in Endocrinology and Metabolism·Rachel E RobertsChanna Jayasena

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