Ovarian dysfunction in mice following chromium (VI) exposure

Toxicology Letters
R C MurthyD K Saxena

Abstract

Chromium (VI) was given through drinking water in two sets of adult Swiss albino female mice in three doses; 250 ppm, 500 ppm and 750 ppm for 20 days in set 1 and 0.05 ppm, 0.5 ppm and 5.0 ppm in set II for 90 days. At the termination of the treatment, the animals of both the sets were euthanized for histopathology, follicle counting, counting of the superovulated ova, duration of estrus cycle and for ultrastructural studies. Ovaries of the highest dose group (750 ppm) showed large numbers of atretic follicles and congestion in stromal tissue compared to the rest of the treated groups. Also, there was a dose-dependent reduction in the number of follicles at different stages of their maturation. The number of ova recovered from superovulated chromium (VI)-treated animals showed significant decreases in the 500 and 750 ppm dosed groups compared to lower dosed (250 ppm) and control groups. The duration of estrus cycle increased in highest dosed (750 ppm) group. A dose-dependent increase in blood chromium level was also seen in treated mice. Ultrastructural observations revealed disintegrated cell membranes of two layered follicular cells and altered villiform mitochondria in thecal cells of 5 ppm dosed group. From the study it was...Continue Reading

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Citations

Jan 1, 2004·Environmental Toxicology and Pharmacology·Usha R AcharyaRashmi R Tripathy
Dec 31, 1996·Toxicology Letters·R K KanojiaR C Murthy
Aug 15, 1998·Toxicology Letters·R K KanojiaR C Murthy
Oct 29, 2011·Biology of Reproduction·Patrick J DevineUlrike Luderer
Feb 14, 2012·Journal of Applied Toxicology : JAT·Ioannis PolyzoisStamatios Theocharis
Jun 13, 2008·Toxicology·Fernanda A QuinterosBeatriz H Duvilanski
Jan 15, 2019·Journal of Women's Health·Kristen UpsonDonna D Baird
Jun 2, 2007·The Journal of Bone and Joint Surgery. British Volume·G M KeeganC P Case
Nov 27, 2014·Human & Experimental Toxicology·P SenguptaS Banerjee
Jul 20, 2021·The Journal of Reproduction and Development·Yuhe TianChao Zhang
Sep 25, 2021·Environmental Science and Pollution Research International·Sulagna DuttaPallav Sengupta

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