Ovarian environment aging: follicular fluid lipidomic and related metabolic pathways

Journal of Assisted Reproduction and Genetics
Fernanda Bertuccez CordeiroEdson Guimaraes Lo Turco

Abstract

The decline in female fecundity with age may be caused by decreased oocyte quality, a factor that may be associated with the altered composition of follicular fluid (FF). In an effort to better understand follicular aging and the role of lipids in a given biological system, we present a prospective study that compares lipid profiles of FF from women older than 35 years (aging group, n = 12) to women equal or younger than 35 years old (control group, n = 17). FF lipids were extracted, and mass spectra were generated using a Waters Synapt G1 Q-TOF in MS mode. MS data was evaluated for both multi- and univariate statistics. The lipids identified as potential biomarkers of follicle aging were attributed by the online databases Lipid Maps, followed by pathway network analysis using Cytoscape software. The in vitro fertilization (IVF) parameters showed significant differences in aging, number of follicles, total number of oocytes and oocytes in MII, and number of injected oocytes. Additionally, FF from the aging group revealed 11 lipids with higher abundance, while FF from the control group included 4 lipids with higher abundance. We suspect that aging may influence lipid metabolism in a downstream cascade leading, ultimately, to dec...Continue Reading

References

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Oct 27, 2015·Journal of Assisted Reproduction and Genetics·Fernanda Bertuccez CordeiroEdson Guimarães Lo Turco
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Citations

Mar 15, 2019·Reproduction : the Official Journal of the Society for the Study of Fertility·Alexandra J Harvey
Jun 14, 2019·Reproductive Biology and Endocrinology : RB&E·Shweta S DipaliFrancesca E Duncan
Oct 12, 2019·Free Radical Biology & Medicine·Irantzu Pérez-RuizJosé-Ignacio Ruiz-Sanz
Nov 13, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jimei XiaoZhengao Sun
Jun 8, 2021·Aging and Disease·Chia-Jung LiKuan-Hao Tsui

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