Ovarian failure following abdominal irradiation in childhood: the radiosensitivity of the human oocyte

The British Journal of Radiology
W H WallaceH R Gattamaneni

Abstract

Ovarian function has been studied sequentially since 1975 in 19 patients treated in childhood for an intra-abdominal tumour with surgery and whole abdominal radiotherapy (total dose 30 Gy). Eleven patients received chemotherapeutic agents that are not known to cause gonadal dysfunction. All but one patient have developed ovarian failure with persistently elevated gonadotrophin levels (FSH and LH greater than 32 IU/litre) and low serum oestradiol values (less than 40 pmol/litre) before the age of 16 years. The majority (n = 12) did not progress beyond breast stage 1 without sex steroid replacement therapy. As the number of oocytes within the ovary declines exponentially by atresia from approximately 2,000,000 at birth to approximately 2000 at the menopause, we have been able to estimate that the LD50 for the human oocyte does not exceed 4 Gy.

References

Aug 1, 1977·British Journal of Cancer·R Himelstein-BrawM Faber
Jun 1, 1976·British Journal of Cancer·S M ShaletD H Orrell
Dec 1, 1987·The Journal of Clinical Endocrinology and Metabolism·S J RichardsonJ F Nelson
May 1, 1988·Archives of Disease in Childhood·E A Livesey, C G Brook
Jan 1, 1968·Annual Review of Medicine·W A Marshall, J M Tanner
Jul 1, 1971·American Journal of Obstetrics and Gynecology·T G Baker
May 1, 1968·The British Journal of Radiology·R Doll, P G Smith
Apr 1, 1980·The British Journal of Radiology·P Ash
Apr 1, 1982·Archives of Disease in Childhood·E WhiteheadD P Deakin
Aug 1, 1958·American Journal of Obstetrics and Gynecology·I I KAPLAN
Feb 16, 1965·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·H M BEAUMONT

❮ Previous
Next ❯

Citations

Jun 5, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M E M Jenney, G A Levitt
Mar 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A B Thomson, W H B Wallace
Mar 29, 2014·Indian Journal of Surgical Oncology·Devika Gunasheela, Sulochana Gunasheela
Aug 22, 2013·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Kohshiro NakaoTakashi Minegishi
Jul 1, 1993·Environmental Health Perspectives·A L Ogilvy-Stuart, S M Shalet
Aug 4, 2001·BMJ : British Medical Journal·W H WallaceUNKNOWN Late Effects Committee of the United Kingdom Children's Cancer Study Group (UKCCSG)
Feb 12, 2005·Journal of Assisted Reproduction and Genetics·M ImhofJ Huber
Dec 16, 2010·Current Opinion in Pediatrics·Jill P Ginsberg
Jul 7, 2011·Indian Journal of Endocrinology and Metabolism·Sanjay KalraWarren Lee
Dec 4, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K Albritton, W A Bleyer
Apr 18, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·W L LeeP H Wang
Jul 16, 2008·Apoptosis : an International Journal on Programmed Cell Death·Dmitri V KryskoKatharina D'Herde
Jan 15, 2003·Human Reproduction·W H B WallaceT W Kelsey
Sep 20, 2012·Journal of Medical Case Reports·Takuma NomiyaKenji Nemoto
Dec 1, 1994·Mutation Research·R JohannissonB Brandenburg
Jan 20, 2009·Human Reproduction Update·I AdriaensP Jacquet
Jul 8, 2005·The New England Journal of Medicine·Rogerio A Lobo
Aug 7, 2002·Current Oncology Reports·Simon J Howell, Stephen M Shalet
Jul 27, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·J K W Yap, M Davies
Nov 19, 2013·Current Problems in Cancer·Michelle GreenePatricia Piasecki
Aug 30, 2011·Journal of Pediatric and Adolescent Gynecology·B LawrenzM Henes
Oct 21, 2015·Critical Reviews in Oncology/hematology·Maria VassilakopoulouAmanda Psyrri
Jul 28, 2009·International Journal of Radiation Oncology, Biology, Physics·Hélène SudourValerie Bernier
Mar 25, 2009·International Journal of Radiation Oncology, Biology, Physics·Jennifer Y Wo, Akila N Viswanathan
Sep 9, 2008·Fertility and Sterility·Jaymeson S StroudPerry W Grigsby
Jan 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Michael SouthArnold C Paulino
Aug 11, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Angela B Edgar, W Hamish B Wallace
Feb 20, 2007·Fertility and Sterility·Patricia FauqueChristophe Roux
Oct 4, 2005·British Journal of Haematology·Mark F H Brougham, W H B Wallace
Mar 21, 2009·Pediatric Blood & Cancer·Kutluk Oktay, Ozgur Oktem
Jun 11, 2009·Pediatric Blood & Cancer·Robert J Johnston, W Hamish B Wallace
Jun 25, 2008·Annals of the New York Academy of Sciences·Ozgur Oktem, Kutluk Oktay
Jul 17, 2013·The Journal of Obstetrics and Gynaecology Research·Samer BarahmehIsam Lataifeh
Mar 8, 2014·CA: a Cancer Journal for Clinicians·Jonathan D KortLynn M Westphal
Aug 30, 2005·Gynécologie, obstétrique & fertilité·H Letur-KönirschS Delanian
Aug 9, 2005·Endocrinology and Metabolism Clinics of North America·Laurie E Cohen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.