Ovarian fibroma/fibrothecoma with elevated serum CA125 level: A cohort of 66 cases

Medicine
Yuanming ShenXiaoyun Wan

Abstract

Ovarian fibroma/fibrothecoma with elevated serum OC125 antigen (CA125) is rarely encountered in clinical practice, and also easily misdiagnosed as epithelial ovarian carcinoma (EOC). The aim of this study was to investigate the clinicopathological features of ovarian fibroma/fibrothecoma with elevated serum CA125.In total, 580 patients who underwent primary surgery and pathologically diagnosed as ovarian fibroma/fibrothecoma were retrospectively analyzed. The clinicopathological parameters were collected and compared between the patients with elevated serum CA125 (>35 U/mL) and without. The immunoreactivity for CA125 in ovarian fibroma/fibrothecoma and epithelial cancer tissues was detected and compared by immunohistochemistry. Univariate and multivariate analyses were performed to identify factors associated with elevated serum CA125 level. The correlation between the immunoreactivity of CA125 in tissue and serum CA125 level was examined by Pearson correlation analysis.Elevated serum CA125 level (range 36.7-1848 u/m) was found in 66 of 580 (11.3%) ovarian fibroma/fibrothecoma patients. Univariate analysis showed that the elevated serum CA125 level was significantly correlated with tumor diameter ≥10 cm (P < .001), ascites (P <...Continue Reading

References

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Citations

Sep 30, 2020·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Tiago Augusto GomesSophie Françoise Derchain
Jun 9, 2020·Journal of Histotechnology·Stephen L StrobelAndrew J Britton
Oct 22, 2020·International Journal of Environmental Research and Public Health·Dagmara PietkiewiczJan Matysiak
Mar 4, 2021·BMJ Case Reports·Alicia PalmieriVerda Hicks
Aug 10, 2021·World Journal of Clinical Cases·Ya-Ya HouMei Zhou

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