Ovarian germ cell tumors in children. Management, survival and ovarian prognosis. A report of 75 cases

Journal of Pediatric Surgery
Charlotte VayssePhilippe Vaysse

Abstract

The aims of this study were to evaluate survival and ovarian prognosis in patients treated for ovarian germ cell tumor (OGCT) and to propose a decision-making protocol. Charts of girls operated on for OGCT from 1976 up to 2009 were reviewed retrospectively. Tumor characteristics were assessed by tumor markers, imaging, and pathology. Charts were available in 71 children presenting 75 OGCT. Tumors were benign in 58 cases and malignant in 17 cases. The average of the largest diameter of benign OGCT was significantly lower than that of malignant OGCT (76.5 +/- 49 mm versus 169 +/- 54 mm, P < .0001). Ovarian-sparing tumorectomy was carried out in 27 benign OGCT; 23 (85%) preserved ovaries were follicular. Malignant OGCTs were managed according to the protocols of the French Society for Pediatric Oncology. Bilateral oophorectomy had to be performed in 2 children. One patient presented a recurrence and 1 died. In our series, both benign and malignant OGCTs have a good prognosis. A 75-mm cutoff size is proposed as an important criterion to preoperatively differentiate between benign and malignant tumors. In benign OGCT, ovarian-sparing tumorectomy leads to preserve ovaries in approximately 85% of cases, and in malignant OGCT, high sur...Continue Reading

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May 14, 2011·Pediatric Radiology·Monica EpelmanSabah Servaes
Dec 12, 2012·Pediatric Surgery International·Rahşan ÖzcanCenk Büyükünal
Jun 28, 2011·Archives of Gynecology and Obstetrics·El-Said Abdel-HadyMaged El-Shamey
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Sep 12, 2018·Journal of Pediatric and Adolescent Gynecology·Charlotte DepoersAlexis Pierre Arnaud
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