Ovarian hormones inhibit fat intake under binge-type conditions in ovariectomized rats.

Physiology & Behavior
Zhiping YuR L W Corwin

Abstract

Binge eating is more common in females than in males. This study investigated the effects of ovarian hormones on binge-eating behavior in a diet-related rat model. Six groups of ovariectomized Sprague-Dawley rats were used (n=13/group). All rats had continuous access to chow and water throughout the study. One half of the rats were injected every fourth day with estradiol benzoate (2 microg/100 microl sesame oil) and progesterone (500 microg/100 microl sesame oil); the other half received only the sesame oil vehicle. Three feeding protocols were tested in each hormone injection condition: (1) chow only: no additional dietary fat access; (2) low-restriction: 1-h fat access every day; (3) high-restriction: 1-h fat access on Monday, Wednesday, and Friday. As previously reported in intact male and female rats, the high-restriction groups exhibited binge-like increases in 1-h energy intake during fat access. The major new finding of this study is that 1-h energy intake was tonically, but not cyclically, reduced in the hormone-treated high-restriction (binge) rats. Specifically, both low- and high-restriction hormone-treated rats consumed significantly less energy than did the oil-treated rats during the 1-h fat period (p<0.0001) and...Continue Reading

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May 18, 2011·Journal of Abnormal Psychology·Kelly L KlumpCheryl L Sisk
Jul 19, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chiara GiulianoBarry J Everitt
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Mar 25, 2021·Clinical Psychological Science : a Journal of the Association for Psychological Science·Kelly L KlumpCheryl L Sisk
Aug 30, 2021·Frontiers in Neuroendocrinology·R G AnversaR M Brown

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