Ovarian hormones modulate endothelin-1 receptor responses in young women

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Kelly N SebzdaMegan M Wenner

Abstract

We recently demonstrated ETBR mediate vasodilation in young but not postmenopausal women; it is unclear if this is related to age or a decline in ovarian hormones. The purpose of this study was to test the hypothesis that ETBR responses are modulated by ovarian hormones. We measured cutaneous vasodilatory responses in 12 young women (22 ± 1 years, 23 ± 1 kg/m2 ) during the ML (days 20-25) and EF (days 2-5) phases of the menstrual cycle. Cutaneous microdialysis perfusions of lactated Ringer (control), ETBR antagonist (BQ-788, 300 nmol/L), and ETAR antagonist (BQ-123, 500 nmol/L) were performed, followed by local heating to 42°C. Serum estradiol (ML: 118 ± 16 vs EF: 44 ± 9 pg/mL, P < 0.05) and progesterone (ML: 8.3 ± 1.0 vs EF: 0.7 ± 0.2 ng/mL, P < 0.05) were higher during ML vs EF phase. ETBR blockade decreased vasodilation during ML (control: 91 ± 2 vs BQ-788: 83 ± 2%CVCmax, P < 0.05) but not EF (control: 89 ± 2 vs BQ-788: 89 ± 1%CVCmax). ETAR blockade also decreased vasodilation during ML (control: 91 ± 2 vs BQ-123: 87 ± 2%CVCmax, P < 0.05) but not EF (control: 89 ± 2 vs BQ-123: 92 ± 2%CVCmax). These data suggest that fluctuations in ovarian hormones modulate ETBR and ETAR responses in young women.

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Citations

Sep 15, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Anna E StanhewiczNina S Stachenfeld
Aug 21, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Leena N ShoemakerMegan M Wenner
Dec 18, 2021·American Journal of Physiology. Heart and Circulatory Physiology·John D AkinsR Matthew Brothers

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