Ovarian hormones modulate endothelin A and B receptor expression

Life Sciences
Eman Y GoharDavid M Pollock

Abstract

The study aims to determine the modulatory roles of ovarian hormones, estrogen (E2) and progesterone (P), on the expression of endothelin A (ETA) and B (ETB) receptors in lung, liver and kidney tissues. Female Sprague-Dawley rats were subjected to bilateral ovariectomy and divided into four groups ovariectomized (OVX), OVX+E2, OVX+P, and OVX+E2+P. A separate group of rats underwent sham surgery and served as a control. Three weeks after OVX or sham surgery, tissues from lungs, liver, renal cortex, and inner medulla were collected, snap-frozen, and kept at -80°C for assessment of ETA and ETB receptor expression using real-time PCR. E2-treated OVX animals had significantly lower expression of ETA receptors in the lungs, compared to OVX rats. Pulmonary ETB receptor mRNA was not measurably affected by any of the interventions. Hepatic ETA and ETB were significantly increased in OVX+E2+P rats, compared to sham rats. Renal inner medullary ETA and ETB receptor expressions were significantly elevated in OVX compared to sham, an effect that was prevented by co-supplementation of OVX with E2 and P. Additionally, both ETA and ETB receptor expression in the renal cortex were significantly attenuated by ovariectomy, and this reduction was n...Continue Reading

References

Apr 1, 1993·The Journal of Clinical Investigation·Y HirataF Marumo
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P SogniD Lebrec
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
Sep 20, 2006·Hormones : International Journal of Endocrinology and Metabolism·Lambrini Gouva, Agathocles Tsatsoulis
Jun 30, 2007·Clinical and Experimental Pharmacology & Physiology·Fung Ping LeungYu Huang
Dec 8, 2007·Clinical Science·Rita C TostesMaria Helena C Carvalho
Sep 17, 2008·Rheumatology·K W Frommer, U Müller-Ladner
Sep 12, 2008·American Journal of Physiology. Renal Physiology·Yuqiang GeDonald E Kohan
Nov 27, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian L StaufferChristopher A Desouza
Jan 21, 2011·Physiological Reviews·Donald E KohanDavid M Pollock
Sep 9, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiromichi Suzuki, Kazuoki Kondo
Mar 1, 2012·British Journal of Pharmacology·W KittikulsuthD M Pollock
Mar 14, 2012·Nature Reviews. Genetics·Christine Vogel, Edward M Marcotte
Mar 16, 2012·Biology of Sex Differences·Kathryn Sandberg, Hong Ji
Apr 18, 2013·Molecular Endocrinology·Yanping ZhangL Bruno Ruest
Aug 16, 2013·American Journal of Physiology. Renal Physiology·Chunhua JinDavid M Pollock
Sep 10, 2014·Kidney & Blood Pressure Research·Kazuyoshi OkadaSusumu Takahashi
Nov 6, 2014·Journal of Menopausal Medicine·Jun-Mo KimTong Wang
Nov 19, 2014·Global Cardiology Science & Practice·Adrian H Chester, Magdi H Yacoub

❮ Previous
Next ❯

Citations

Feb 17, 2018·British Journal of Pharmacology·Margaret A MouatNicola J Smith
May 5, 2017·American Journal of Physiology. Renal Physiology·Eman Y GoharDavid M Pollock
Jul 13, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kelly N SebzdaMegan M Wenner
Jan 31, 2018·Nature Reviews. Nephrology·Katrina M Mirabito Colafella, Kate M Denton
Jun 20, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Andrew V KuczmarskiMegan M Wenner
Mar 5, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ellen E GillisJennifer C Sullivan
Jan 5, 2019·Biology of Sex Differences·Eman Y GoharEdward W Inscho
Mar 7, 2020·Scientific Reports·Haissa Oliveira BritoAleksander Roberto Zampronio
Jan 9, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Reham H SolimanDavid M Pollock
Jun 10, 2018·Current Hypertension Reports·Eman Y Gohar, David M Pollock
May 12, 2020·Journal of the American Heart Association·Eman Y GoharDavid M Pollock
Nov 1, 2020·The Journal of Pharmacology and Experimental Therapeutics·Eman Y Gohar, David M Pollock
Jun 3, 2021·International Journal of Molecular Sciences·Alice PierreStéphanie Chauvin
Aug 10, 2021·The EPMA Journal·Adriana Torres CrignaOlga Golubnitschaja
Aug 21, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Leena N ShoemakerMegan M Wenner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.