Ovarian influence on mitogen responsiveness of lymphocytes from mice neonatally exposed to diethylstilbestrol

Journal of Toxicology and Environmental Health
T Kalland

Abstract

Treatment of neonatal female mice with diethylstilbestrol (DES) resulted in a reduced response of spleen lymphocytes to concanavalin A (Con A) and lipopolysaccharide (LPS). Ovariectomy or ovariectomy plus estradiol treatment had no influence on the response to Con A in either control or DES-treated females. Ovariectomy reduced the response to LPS in control animals and eliminated the difference between control and DES-treated females. Estradiol treatment enhanced the response of ovariectomized control females to LPS and restored the difference between control and DES-treated animals. Comparison of the mitogen responsiveness during various stages of the estrous cycle showed a tendency for the response to be augmented at proestrus and metestrus, although the differences were not significant.

References

Nov 1, 1976·Journal of the National Cancer Institute·T MoriP N Young
Oct 1, 1978·Bulletin of Environmental Contamination and Toxicology·M I LusterJ A McLachlan
Feb 1, 1979·Toxicology and Applied Pharmacology·M I LusterG C Clark
Feb 1, 1978·Experimental and Molecular Pathology·T KallandJ G Forsberg
Mar 1, 1978·Cancer Letters·T Kalland, J G Forsberg
Feb 1, 1976·Infection and Immunity·J F KennyG Trail
Sep 1, 1977·Journal of Toxicology and Environmental Health·R A GorskiL W Christensen
Nov 1, 1976·British Journal of Obstetrics and Gynaecology·R A Karmali, D F Horrobin
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Oct 1, 1952·Physiological Reviews·T F DOUGHERTY

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