Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system

The Journal of Clinical Investigation
Adrian ErlebacherLaurie H Glimcher

Abstract

We describe a murine model of early pregnancy failure induced by systemic activation of the CD40 immune costimulatory pathway. Although fetal loss involved an NK cell intermediate, it was not due to lymphocyte-mediated destruction of the fetus and placenta. Rather, pregnancy failure resulted from impaired progesterone synthesis by the corpus luteum of the ovary, an endocrine defect in turn associated with ovarian resistance to the gonadotropic effects of prolactin. Pregnancy failure also required the proinflammatory cytokine TNF-alpha and correlated with the luteal induction of the prolactin receptor signaling inhibitors suppressor of cytokine signaling 1 (Socs1) and Socs3. Such links between immune activation and reproductive endocrine dysfunction may be relevant to pregnancy loss and other clinical disorders of reproduction.

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Citations

Jul 14, 2006·Springer Seminars in Immunopathology·Ana Claudia Zenclussen
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jonathan E BoysonJack L Strominger
Feb 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yeny Martinez de la TorreAlberto Mantovani
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Aug 15, 2013·Obstetrical & Gynecological Survey·Jaume Alijotas-Reig, Carmen Garrido-Gimenez
Apr 21, 2007·The Journal of Clinical Investigation·Adrian ErlebacherLaurie H Glimcher
Jun 24, 2009·The Journal of Clinical Investigation·Mary K CollinsAdrian Erlebacher
Apr 7, 2010·The Journal of Clinical Investigation·Hyunjung Jade Lim, Haibin Wang
Jul 23, 2013·The Journal of Clinical Investigation·Alison S CareSarah A Robertson
Aug 28, 2013·The Journal of Clinical Investigation·Jeeyeon ChaYasushi Hirota
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Mar 23, 2010·Trends in Endocrinology and Metabolism : TEM·Adrian Erlebacher
Mar 17, 2015·The Journal of Clinical Investigation·María Emilia SolanoPetra Clara Arck

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

CellQuest

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