Ovarian malignant Mullerian mixed tumor (heterologous) whose epithelial component is composed predominantly of signet ring cell carcinoma

Archives of Gynecology and Obstetrics
Tadashi Terada

Abstract

Ovarian malignant Mullerian mixed tumor (MMMT) (carcinosarcoma) is a relatively rare, very aggressive tumor. Herein is presented an unusual case of heterologous MMMT with an epithelial element composed predominantly of signet ring cell carcinoma. A 60-year-old Japanese woman consulted our hospital because of a pelvic mass. Imaging modalities showed a huge tumor of the right ovary. Laparotomy was performed, and frozen section showed a malignant tumor. Therefore, hysterectomy, bilateral salpingo-oophorectomy, lymph node dissection, and omentectomy were performed. On gross examination, the right ovarian tumor was solid, measuring 12 × 13 × 12 cm. The surface was smooth but bosselated. Histologically, the tumor was composed of epithelial and sarcomatous elements. Curiously, the epithelial element was composed predominantly of signet ring cell carcinoma. A small area showed tubular adenocarcinoma and poorly differentiated carcinoma. The sarcomatous element was homologous with spindle cell sarcoma with many mitotic cells. The signet ring cells had mucins. Immunohistochemically, the epithelial element was positive for cytokeratins, EMA, p53, CEA, CA19-9, and Ki-67 (labeling = 75%). The sarcomatous element was positive for vimentin, α-...Continue Reading

References

Apr 11, 2003·Pathology International·Tadashi TeradaYoshiyuki Osamura
Nov 6, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mauro PapottiJuan Rosai
Jun 9, 2005·The Tohoku Journal of Experimental Medicine·Tadashi Terada, Masaharu Kawaguchi
Mar 16, 2006·The American Journal of Surgical Pathology·Takako KiyokawaRobert E Scully

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Citations

May 16, 2013·Journal of Gastrointestinal Cancer·Tadashi Terada
Jun 15, 2017·American Journal of Obstetrics and Gynecology·Carmen GanRanjit Manchanda

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