Ovarian mesonephric-like adenocarcinoma arising in serous borderline tumor: a case report with complex morphological and molecular analysis.

Diagnostic Pathology
P DundrDaniela Fischerová

Abstract

Mesonephric-like adenocarcinoma (M-LAC) is a rare, recently described tumor occurring in the uterine corpus and ovary, which shares the same morphological and immunohistochemical features with the more common mesonephric adenocarcinoma (MAC), which mostly arises the uterine cervix. Despite the similarities between these tumors, the histogenesis of M-LAC is still disputable. Sixty-one-year-old woman presented with an advanced tumor of the left ovary with intraabdominal spread and liver metastases. After receiving 5 cycles of neoadjuvant chemotherapy, she underwent a hysterectomy with bilateral salpingo-oophorectomy, and resection of the liver metastasis, omentum, and appendix. Histologically, the ovarian tumor consisted of two components, whose morphology and immunohistochemical results were typical of either a serous borderline tumor (immunohistochemical positivity for PAX8, WT1, ER and PR) or a mesonephric-like carcinoma (immunohistochemical positivity for PAX8, TTF1 and GATA3). Only the component of the mesonephric-like adenocarcinoma metastasized to the omentum and liver. A molecular analysis with a panel of 271 genes (size 1020 kbp) was performed separately on samples from the borderline tumor, primary ovarian mesonephric-l...Continue Reading

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Citations

Feb 23, 2021·Frontiers in Oncology·Ruochen LiuHongjuan Cui
Mar 28, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Edaise M da SilvaKay J Park
Aug 11, 2021·Surgical Pathology Clinics·Zehra OrduluLauren L Ritterhouse
Sep 29, 2021·The Journal of Obstetrics and Gynaecology Research·Mari UjitaIkuo Konishi

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Methods Mentioned

BETA
hysterectomy

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