Ovarian Microcystic Stromal Tumor: A Case Report and Literature Review

Frontiers in Medicine
Lin DengBin Ling

Abstract

Background: Microcystic stromal tumor is a recently described subtype of ovarian tumor characterized by microcystic pattern and diffuse immunoreactivity for CD10, vimentin, and β-catenin and negative for EMA. However, its diagnostic criterion and standard treatment remain unclear. Case presentation: We report a rare case of a left side microcystic stromal tumor with diameter about 7 cm in a 25-year-old female and summarize all cases of MCST reported in this study. The present patient underwent left ovarian tumor resection. Generally, the tumor was solid and cystic mixed. Immunohistochemically, the tumor was expressed CD10, WT1, cyclin D1 and vimentin, and nuclear immunoreactivity for β-catenin but negative for α-inhibin, calretinin, CK AE1/AE3, PLAP, SALL-4, CK7, P53, EMA, CD99, AFP, desmin, CgA, E-cadherin, and melanA. Conclusion: Unilateral ovary, solid-cystic, and a larger than 4-8 cm pelvic mass without serious abdominal pain are its clinical features. The immunophenotype of vimentin+/CD10+/WT-1+/β-catenin+(nuclei)/cyclin D1+ is supportive of diagnosis. For these patients, unilateral oophorectomy dissection could be selected.

References

Oct 31, 2008·The American Journal of Surgical Pathology·Julie A Irving, Robert H Young
Sep 2, 2011·The American Journal of Surgical Pathology·Daichi MaedaMasashi Fukayama
Apr 2, 2014·Ultrastructural Pathology·Mary Yang, Meenakshi B Bhattacharjee
Feb 13, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Yu Na KangSun Young Kwon
Mar 31, 2015·Genes, Chromosomes & Cancer·Sang Hun LeeYong-Soon Kwon
Jun 25, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Varsha PodduturiShirley Michelle Shiller
Mar 24, 2016·Obstetrics & Gynecology Science·Jae Hoon LeeEun Ji Nam
Nov 11, 2016·Virchows Archiv : an International Journal of Pathology·Alexandra MeurgeyMojgan Devouassoux-Shisheboran
Jul 1, 2017·Gynecology and Minimally Invasive Therapy·Midori MurakamiHidehiro Kawagoe
Oct 17, 2018·Histopathology·W Glenn McCluggageWilliam D Foulkes

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Methods Mentioned

BETA
dissect
hysterectomy
dissection

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