Ovarian minimal residual disease in chronic myeloid leukaemia

Reproductive Biomedicine Online
Ronit AbirBenjamin Fisch

Abstract

The options for fertility preservation include cryopreservation of ovarian tissue. Although transplantation of cryopreserved-thawed ovarian tissue in cancer survivors has resulted in live births, there is evidence of malignancy involvement in ovarian tissue, especially in leukaemia. The objectives of this study were to investigate the involvement of chronic myeloid leukaemia (CML) in ovaries by both pathological/immunohistochemical methods and PCR for the identification of the Philadelphia chromosome (BCR-ABL transcripts). The patient was a survivor of paediatric CML whose ovaries were cryopreserved. The patient became infertile and requested ovarian reimplantation in adulthood. Pathological examinations of ovarian tissue with immunohistochemical stainings, quantitative PCR and two-step nested PCR were applied to identify BCR-ABL transcripts. Despite the lack of positive pathological/immunohistochemical evidence, PCR and two-step nested PCR revealed that the ovary was contaminated by malignant minimal residual CML. Survivors of childhood CML may harbour minimal residual disease in the ovaries. This finding stresses the danger of reseeding cancer by ovarian grafting, especially in patients with leukaemia. If ovarian grafting is ...Continue Reading

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Citations

May 23, 2014·Journal of Assisted Reproduction and Genetics·Monica M LarondaTeresa K Woodruff
Mar 28, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Benjamin Fisch, Ronit Abir
Apr 29, 2018·Biotechnology and Bioengineering·Peter D RiosLonnie D Shea
May 8, 2019·Journal of Tissue Engineering and Regenerative Medicine·Eun ChoSeung-Yup Ku
Feb 2, 2017·Reproduction, Fertility, and Development·Assiel J YounisRonit Abir
Apr 19, 2017·British Journal of Haematology·Michelle SoaresMarie-Madeleine Dolmans
Aug 23, 2019·Clinical Medicine Insights. Reproductive Health·Laura LotzMatthias W Beckmann
Feb 10, 2018·PloS One·Riccardo TaleviRoberto Gualtieri
Jan 5, 2021·Human Reproduction·Thu Yen Thi NguyenMarie-Madeleine Dolmans
Mar 17, 2021·Journal of Assisted Reproduction and Genetics·Lotte EijkenboomRonald Peek

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