PMID: 15381910Sep 24, 2004Paper

Ovarian non-small cell neuroendocrine carcinoma with paraneoplastic parathyroid hormone-related hypercalcemia

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Satoshi OhiraIkuo Konishi

Abstract

Ovarian tumors associated with hypercalcemia due to ectopic secretion of parathyroid hormone (PTH) are extremely rare. A 33-year-old woman presented with a pelvic mass and profound hypercalcemia accompanied by an elevated serum level of PTH. Laparotomy demonstrated a left ovarian tumor that on histological examination was a neuroendocrine carcinoma of non-small cell type admixed with a component of endometrioid adenocarcinoma. After left salpingo-oophorectomy, the serum calcium and PTH levels normalized. The cells of the neuroendocrine carcinoma were positive for neuron-specific enolase, synaptophysin, chromogranin A, and PTH. Hypercalcemia and elevated serum PTH levels recurred during tumor relapse, and the patient died of disease 6 months postoperatively. This is the eleventh case of neuroendocrine carcinoma of non-small cell type associated with surface epithelial neoplasm of the ovary, and the first such tumor to be associated with hypercalcemia.

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Citations

Apr 27, 2007·The American Journal of Surgical Pathology·Emanuela VerasAnais Malpica
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Marie GrandjeanEtienne Marbaix
Dec 3, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Hironao YasuokaYasushi Nakamura
Jul 16, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M F AslamN Khulpateea
Oct 23, 2013·Seminars in Diagnostic Pathology·Marjan Rouzbahman, Blaise Clarke
Jul 16, 2014·Taiwanese Journal of Obstetrics & Gynecology·Dah-Ching DingYung-Hsiang Hsu
Jan 1, 2008·Pathology, Research and Practice·Pavel DundrDavid Cibula
Jan 19, 2007·Gynecologic Oncology·Yoo Duk ChoiJong Hee Nam
Jan 15, 2013·Gynecologic Oncology·Gary G Schwartz, Halcyon G Skinner
Jan 31, 2006·Arquivos brasileiros de endocrinologia e metabologia·Maria Lucia F de Farias
Feb 14, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C F Lindboe
Mar 19, 2020·Clinical Case Reports·Franchesca Gabrielle Concha Gabriel, Rosalina Espiritu Picar
Apr 17, 2014·The Journal of Obstetrics and Gynaecology Research·Kayo AsadaTomoyuki Fujii
Aug 1, 2018·Expert Review of Endocrinology & Metabolism·Agedi N Boto, Pei Hui
Sep 15, 2012·Experimental and Therapeutic Medicine·Takafumi OshitaMayumi Kaneko
Jun 15, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Eric J MahoneyRonald De Lellis
Nov 17, 2020·Rare Tumors·Grant BurkeenSusanne Arnold
May 3, 2021·Critical Reviews in Oncology/hematology·Giuseppe CarusoInnocenza Palaia
Jul 10, 2021·The Journal of Clinical Endocrinology and Metabolism·Yasaman MotlaghzadehDeborah E Sellmeyer

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