Ovarian organogenesis in mammals: mice cannot tell us everything

Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
Rafael Jiménez

Abstract

The mammalian ovary shows extensive variation mainly in relation to the interstitial tissue of the ovary, the so-called interstitial gland, and the degree of gonad regionalisation, which implies the existence of a cortex and a medulla. Three mammalian species, mouse, human, and mole, have been reviewed here as representative animal models for ovarian variability. Whereas the human ovary may be considered to have a conventional pattern of development, the mouse and the mole represent the two extremes of the variation range. The mouse is exceptional among mammals because ovarian regionalisation is much less relevant than in other species. Contrarily, the mole ovary is very similar to that of humans regarding the cortical region, but shows a testis-like pattern of development in the medullary region. Thus, the mole ovary is in fact an ovotestis, a phenomenon also described in other mammals. Accordingly, current studies on the development of the mouse ovary are not sufficient to understand the process in a more general context, because ovarian organogenesis is exceptionally simple in the mouse. From an evolutionary perspective, mammals show a tendency to eliminate or reduce gonad regionalisation, in contrast with the situation in o...Continue Reading

Citations

Jul 31, 2012·PloS One·Huijun ChenDagmar Wilhelm
Feb 15, 2013·PloS One·Katja HummitzschRaymond J Rodgers
May 1, 2012·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Darío G LupiáñezRafael Jiménez
Dec 1, 2011·Biomolecular Concepts·Francisco BarrionuevoRafael Jiménez
Aug 16, 2013·Biology of Reproduction·Francisca M RealMiguel Burgos
Aug 1, 2012·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·S G Tevosian
Apr 22, 2019·Reproduction in Domestic Animals = Zuchthygiene·Aline F de SouzaDaniele S Martins
Mar 4, 2020·Zygote : the Biology of Gametes and Early Embryos·Tania Janeth Porras-Gómez, Norma Moreno-Mendoza
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Aline Fernanda de SouzaDaniele Dos Santos Martins
Mar 28, 2021·Journal of Assisted Reproduction and Genetics·Parinaz AsiabiChristiani A Amorim

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