Ovarian receptors for insulin and insulin-like growth factor I (IGF-I) and effects of IGF-I on steroid production by isolated follicular layers of the preovulatory coho salmon ovarian follicle

General and Comparative Endocrinology
M A MaestroP Swanson

Abstract

In this study, receptors for insulin and insulin-like growth factor I (IGF-I) in isolated theca-interstitial layers and granulosa cells of the coho salmon preovulatory ovary were characterized, and the effects of IGF-I on ovarian steroidogenesis were examined. Specific receptors for insulin and IGF-I were found in granulosa and theca-interstitial layers. In both follicular layers, IGF-I receptors were greater in number and higher in affinity than insulin receptors. The effects of IGF-I on in vitro production of testosterone (T) and 17 alpha-hydroxyprogesterone (17OH-P) by theca-interstitial layers and of 17 beta-estradiol (E2) and 17 alpha, 20 beta-dihydroxy-4-pregnen-3-one (17,20 beta-P) by granulosa cell layers were evaluated during the preovulatory period. Both human and salmon recombinant IGF-I inhibited the basal and GTH II-stimulated T and 17OH-P production by theca-interstitial layers throughout the preovulatory period. In contrast, IGF-I stimulated the production of both E2 and 17,20 beta-P by granulosa cell layers prior to germinal vesicle breakdown (GVBD) but only stimulated the production of 17,20 beta-P by granulosa cell layers after GVBD. The inhibitory effects of IGF-I on steroid production by the theca-interstiti...Continue Reading

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Citations

Jan 22, 2013·Fish Physiology and Biochemistry·Benjamin GeffroyAgnès Bardonnet
Mar 11, 2011·Journal of Toxicology and Environmental Health. Part a·Nela Pavlikova, Augustine Arukwe
May 8, 2010·General and Comparative Endocrinology·Sharon N Nelson, Glen Van Der Kraak
Jun 10, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Marian PonceManuel Manchado
Feb 10, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S WuertzW Kloas
Feb 27, 2007·General and Comparative Endocrinology·Gregory M WeberCraig V Sullivan
Aug 27, 2010·Journal of Fish Biology·W-T Huang, C-F Weng
Oct 12, 2004·General and Comparative Endocrinology·Donald A LarsenWalton W Dickhoff
Jul 29, 2006·General and Comparative Endocrinology·B Scott Nunez, Scott L Applebaum
Jun 21, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Yoji YamamotoPenny Swanson
Dec 9, 2016·Zygote : the Biology of Gametes and Early Embryos·Luís Henrique Montrezor, Elisabeth Criscuolo Urbinati
Oct 30, 2009·Biology of Reproduction·Manfred Reinecke
Nov 19, 2010·Biology of Reproduction·Jianzhen LiChristopher H K Cheng
Jul 3, 2002·General and Comparative Endocrinology·H DuvalD Boujard

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