Ovarian reserve in women with sickle cell disease

PloS One
Julia KopeikaEugene Oteng-Ntim

Abstract

It has been proposed that ovarian sickling and/or iron overload in women with sickle cell disease (SCD) could contribute to gonadal dysfunction, but there are very few published studies. We hypothesised that the above phenomena might impair ovarian reserve. A total of 50 SCD patients were case-matched by age, ethnicity, and presence of regular cycles (28±5 days) with 73 patients without a known haemoglobinopathy who required anti-Müllerian hormone (AMH) assessment in a gynaecology clinic. SCD patients had AMH levels taken as part of routine care. The patients were case-controlled and matched with patients who had no haemoglobinopathy in a tertiary centre over a period of one year. The mean AMH in the SCD case group was 7.6 pmol/l compared with 13.4 pmol/l in the control group (p<0.001). The AMH distributions were subsequently categorised. This showed that SCD patients had a significantly higher chance of having lower AMH in comparison with the control group (OR 2.6 (CI 1.1-6.5, P = 0.02). The proportion of women with AMH > 20 pmol/l was significantly lower in the SCD group (6%) in comparison with the control group (19%) (P = 0.04). This is the first study showing that women of reproductive age with SCD are more likely to have a...Continue Reading

References

Nov 1, 1976·Annals of Internal Medicine·A A AbbasiD Oberleas
Feb 3, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G Breart
Jun 1, 1997·Maternal and Child Health Journal·K E HeckJ L Kiely
Oct 23, 2001·Archives of Disease in Childhood·G R SerjeantI R Hambleton
Nov 29, 2002·Human Reproduction·I A J van RooijA P N Themmen
Apr 16, 2005·Human Reproduction Update·D T BairdUNKNOWN ESHRE Capri Workshop Group
Jan 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jenny A VisserAxel P N Themmen
Nov 18, 2006·Fertility and Sterility·Ellen W FreemanJerome F Strauss
Mar 6, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Asli SomunkiranIsmail Ozdemir
Oct 22, 2008·Fertility and Sterility·David B SeiferRuth M Greenblatt
Feb 18, 2010·Contraception·Anne Z SteinerAlison Edelman
Aug 17, 2010·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Samir HalawatyHesham Al-Inany
Dec 7, 2010·Lancet·David C ReesMark T Gladwin
Mar 16, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·H-H ChangK-H Lin
Oct 15, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S DebN J Raine-Fenning
May 30, 2012·Clinical Endocrinology·Richard A Anderson
Jun 2, 2012·Journal of Public Health·Ghida AljuburiAzeem Majeed
Sep 12, 2012·Reproductive Biology and Endocrinology : RB&E·Norbert GleicherDavid H Barad
Jan 17, 2014·Human Reproduction Update·Didier DewaillyRichard A Anderson
Aug 5, 2014·Journal of Neuro-oncology·Jenny N PoynterJulie A Ross
Oct 5, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·C A SchramE Tullis
Nov 6, 2014·Military Medicine·Bryant J Webber, Catherine T Witkop
Dec 5, 2014·Blood·Kim Smith-Whitley
Aug 19, 2015·Reproductive Biomedicine Online·Richard FlemingJane Ruman
Jan 14, 2016·Blood·Leslie V Parise, Nancy Berliner
Mar 16, 2016·Disease Markers·Zehra JamilRabia Malik
Jul 22, 2016·Blood·Kate GardnerSwee Lay Thein

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Citations

Jul 8, 2021·British Journal of Haematology·Lydia H PeckerKim Smith-Whitley
Aug 19, 2020·Hematology, Transfusion and Cell Therapy·Ana Mach QueirozSamir K Ballas

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