Ovarian response and outcome of in-vitro fertilization in patients treated with gonadotrophin-releasing hormone analogues in different phases of the menstrual cycle

Human Reproduction
A PellicerF Bonilla-Musoles

Abstract

Gonadotrophin-releasing hormone analogues (GnRH-a) are currently used in combination with gonadotrophins in ovarian stimulation for in-vitro fertilization (IVF). The present study evaluates follicular recruitment and outcome of IVF in patients treated with GnRH-a, starting in different phases of the menstrual cycle. Ovarian quiescence was achieved by s.c. injection of a GnRH-a (600 micrograms/day). Three groups of patients were randomly established. Patients in group 1 (n = 14) started GnRH-a treatment 4-7 days after ovulation. Women in group 2 (n = 15) started GnRH-a 8-10 days after ovulation. Patients in group 3 (n = 15) began the analogue 1-3 days after the onset of menses. Multiple follicular development was achieved by a combination of pure follicle-stimulating hormone and human menopausal gonadotrophin. Oocyte collection was performed 35 h after administration of human chorionic gonadotrophin. Luteolysis was successfully induced in 15% of cases in group 1 and 40% in group 2. Ovarian arrest was achieved in a significantly (P less than 0.01) shorter period of time in group 3 in comparison to groups 1 and 2. There was no difference between groups in the dose of gonadotrophins necessary to reach an optimal response. Patients ...Continue Reading

Citations

Jan 26, 2006·Endocrine Reviews·Nick S MacklonBart C J M Fauser
Jun 1, 1992·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F MiróA Pellicer
Nov 1, 1993·British Journal of Obstetrics and Gynaecology·P VandekerckhoveT W Harada
Aug 1, 1997·The Journal of Clinical Endocrinology and Metabolism·C SimónA Pellicer
Jul 30, 2018·Journal of Assisted Reproduction and Genetics·Israel OrtegaAntonio Pellicer
Dec 22, 2016·Archives of Gynecology and Obstetrics·Lena Sagi-DainMartha Dirnfeld
Nov 16, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yudi GengLei Jin
Nov 13, 2015·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisSiladitya Bhattacharya
Oct 24, 1998·Journal of Reproductive Immunology·A PellicerC Simón
Oct 24, 1998·Journal of Reproductive Immunology·C SimónA Pellicer
Oct 7, 2008·Animal Reproduction Science·Atunga NyachieoThomas M D'Hooghe

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