Ovarian response to combined growth hormone-gonadotropin treatment in patients resistant to induction of superovulation

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
A VolpeA R Genazzani

Abstract

The efficacy of combined growth hormone (GH)-gonadotropin treatment has been studied in patients previously resistant to sole gonadotropins for induction of superovulation. Eleven patients (aged 26-41) with a mechanical cause of infertility were treated. All were given the same dosage of gonadotropins as in previous cancelled cycles (6-17 ampules/cycle of menofollitropin; 34-80 ampules/cycle of human menopausal gonadotropin) plus a standard dosage of GH (0.1 IU per kg body weight, daily). Younger patients (n = 6, age 26-36) showed a considerable improvement of ovarian response in terms of number of mature follicles aspirated by laparoscopy (performed on day 11-13). Older patients (n = 5, age 39-41) did not show any significant improvement of ovarian response with combined treatment and all had their stimulatory cycle cancelled. Follicular fluid (FF) levels of GH, 17 beta-estradiol (E2) and progesterone (P) were significantly higher in the group of younger GH-treated patients (n = 53 follicles) than in 4 controls treated with gonadotropins only (n = 32 follicles). FF insulin-like growth factor-I (IGF-I) did not significantly differ between the two groups. A significant positive linear correlation has been found between FF GH and...Continue Reading

References

May 1, 1987·Fertility and Sterility·A PellicerA H DeCherney
Jul 1, 1988·Clinical Endocrinology·R HomburgH S Jacobs

❮ Previous
Next ❯

Citations

Jun 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·Z Blumenfeld
May 1, 1996·Journal of Assisted Reproduction and Genetics·R Homburg, Z Ben-Rafael
Apr 1, 1994·Journal of Assisted Reproduction and Genetics·C HuyserP F Levay
Sep 1, 1993·Molecular and Cellular Endocrinology·B CarlssonH Billig
Jan 16, 1995·The American Journal of Medicine·R P Buyalos
Oct 24, 1998·Journal of Reproductive Immunology·A PellicerC Simón
Dec 1, 1996·Journal of Endocrinological Investigation·P G ArtiniG D'Ambrogio
Jun 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·Z ShohamH S Jacobs
Jun 1, 1993·Baillière's Clinical Obstetrics and Gynaecology·R Homburg
Jul 1, 1994·Clinical Endocrinology·Z ShohamH S Jacobs
Nov 8, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·B M WeallG Almahbobi
Jan 1, 1991·Annals of the New York Academy of Sciences·B LunenfeldV Insler
Jan 1, 1991·Annals of the New York Academy of Sciences·C BerghT Hillensjö
Dec 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Z Ben-RafaelD Feldberg
Jan 1, 1996·Journal of Geriatric Psychiatry and Neurology·K M BeusterienJ E Ware

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.