Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation

Journal of Pediatric and Adolescent Gynecology
Amy M LukeSusan L Whiteway

Abstract

Ovarian tumors, although uncommon in children, can retain endocrine function that disrupts normal feedback mechanisms leading to amenorrhea. Inheritance of germline DICER1 mutations can lead to increased risk for development of ovarian Sertoli-Leydig cell tumors (SLCTs). We report, to our knowledge, the first case of secondary amenorrhea due to elevated inhibin B levels in a female adolescent with an ovarian SLCT. Ovarian tumors should be included in the differential diagnosis for pediatric patients who present with menstrual irregularities. Early evaluation of the hypothalamic-pituitary-ovarian axis and inhibin levels is appropriate. Our case also emphasizes the need for testing for DICER1 mutations in pediatric patients with ovarian SLCTs.

References

Mar 15, 1987·Cancer·R B RaneyP Littman
Jun 14, 2012·The Journal of Obstetrics and Gynaecology Research·Rani Akhil BhatKwai Lam Yam
Nov 20, 2016·Journal of Oncology Practice·Kris Ann P SchultzA Lindsay Frazier

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Citations

May 1, 2021·Journal of Clinical Medicine·Elisa De PaolisPaola Concolino
Jul 21, 2021·Journal of Pediatric and Adolescent Gynecology·Katherine G Hayes, Amanda V French

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