Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats

Neurobiology of Learning and Memory
Alicia A WalfCheryl A Frye

Abstract

Learning and memory processes may be influenced by fluctuations in steroid hormones, such as estrogens and progestins. In this study, we have used an animal model to investigate the effects of endogenous fluctuations in ovarian steroids in intact female rats and effects of administration of ovarian steroids to ovariectomized rats for non-spatial, working memory using the object recognition task. Performance in this task relies on cortical and hippocampal function. As such, serum, cortical, and hippocampal concentrations of estradiol (E2), progesterone (P4), and P4's metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), were measured by radioimmunoassay. Experiment 1: Rats in behavioral estrus, compared to those in diestrus or estrus, spent a greater percentage of time exploring a novel object concomitant with increases in serum E2, P4, and 3alpha,5alpha-THP levels. Regression analyses revealed that there was a significant positive relationship between E2 levels in the hippocampus and 3alpha,5alpha-THP levels in the hippocampus and cortex and performance in this task. Experiment 2: Administration of E2 and/or P4 immediately post-training increased the percentage of time spent exploring the novel object and produced le...Continue Reading

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Citations

Jul 3, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Thomas C FosterSusan L Semple-Rowland
Sep 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Deepak P SrivastavaPeter Penzes
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Caroline C SmithLori L McMahon
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