Ovarian stimulation for in vitro fertilization in low-responder patients using pulsatile intravenous follicle stimulating hormone

Journal of in Vitro Fertilization and Embryo Transfer : IVF
M C EdelsteinS J Muasher

Abstract

There is a subset of patients who fail to respond adequately to exogenous gonadotropin stimulation for in vitro fertilization (IVF). In this study, six such low-responder patients who had inadequate stimulations with high-dose intramuscular (im) follicle stimulating hormone (FSH) were treated in a subsequent cycle with pulsatile intravenous (iv) FSH. A paired analysis was performed to compare the cycles using high-dose im FSH with those using pulsatile iv FSH. Trough serum FSH levels were significantly higher with pulsatile iv FSH. No significant difference was noted in the stimulation characteristics or the number or quality of oocytes retrieved and embryos transferred. No pregnancies occurred in either group. While pulsatile iv administration of gonadotropin increases serum FSH levels, it does not appear to have a major impact on follicular stimulation or outcome in low-responder patients undergoing IVF.

References

Oct 1, 1989·Journal of in Vitro Fertilization and Embryo Transfer : IVF·G E HofmannG S Jones
Aug 1, 1987·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S Friedler, Y Z Diamant
Jan 1, 1988·Annals of the New York Academy of Sciences·S J Muasher
Apr 1, 1972·The Journal of Clinical Endocrinology and Metabolism·S S YenL Ajabor
Dec 1, 1984·Clinical Obstetrics and Gynecology·D F Archer

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Citations

Sep 1, 1990·Baillière's Clinical Obstetrics and Gynaecology·S Oehninger, G D Hodgen
Sep 1, 1992·Journal of Endocrinological Investigation·B S HurstG D Berkovitz

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