Ovarian stimulation in patients with breast cancer

Ecancermedicalscience
Elkin MuñozJuan A García Velasco

Abstract

Breast cancer is the most prevalent malignancy among women under 50. Improvements in diagnosis and treatment have yielded an important decrease in mortality in the last 20 years. In many cases, chemotherapy and radiotherapy develop side effects on the reproductive function. Therefore, before the anti-cancer treatment impairs fertility, clinicians should offer some techniques for fertility preservation for women planning motherhood in the future. In order to obtain more available oocytes for IVF, the ovary must be stimulated. New protocols which prevent exposure to increased estrogen during gonadotropin stimulation, measurements to avoid the delay in starting anti-cancer treatment or the outcome of ovarian stimulation have been addressed in this review. There is no evidence of association between ovarian stimulation and breast cancer. It seems that there are more relevant other confluent factors than ovarian stimulation. Factors that can modify the risk of breast cancer include: parity, age at full-term birth, age of menarche, and family history. There is an association between breast cancer and exogenous estrogen. Therefore, specific protocols to stimulate patients with breast cancer include anti-estrogen agents such as letrozo...Continue Reading

Citations

May 2, 2017·Journal of Adolescent and Young Adult Oncology·Pietro BortolettoMary Ellen Pavone
Jun 24, 2016·Annals of Surgical Oncology·Devina K S McCrayStephanie A Valente
Nov 30, 2019·Current Treatment Options in Oncology·Lorenzo RossiOlivia Pagani

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