Ovarian Stimulation Protocol in IVF: An Up-to-Date Review of the Literature

Current Pharmaceutical Biotechnology
Alessandro PacchiarottiArianna Pacchiarotti

Abstract

The Assisted Reproductive Technology (ART) was born in order to help couples with infertility issues in having a baby. The first treatments of IVF used the spontaneous cycle of the women, with the retrieval of only one oocyte. Further studies have shown that it is possible to induce ovulation by administrating gonadotropins during the menstrual cycle, in order to obtain a higher number of oocytes. Many stimulation protocols have been introduced for controlled ovarian hyperstimulation of patients undergoing in vitro fertilization treatment. This review describe the different stimulation protocols using follicle-stimulating hormone (FSH) in combination with Gonadotropin releasing hormone (GnRH) either agonist or antagonist, oral supplementations and ovarian triggering. Using GnRH antagonist protocols have been demonstrated to improve significantly the clinical pregnancy rates for expected poor and high-responders, and in those women at high risk of developing ovarian hyperstimulation syndrome (OHSS). Two meta-analyses showed a better outcome in terms of the live birth rate when highly purified human menopausal gonadotropin (HMG) was used for ovarian stimulation compared with recombinant follicle stimulating hormone (rFSH) in the ...Continue Reading

Citations

Oct 6, 2018·Journal of Peptide Science : an Official Publication of the European Peptide Society·Juan M Gurevich MessinaSilvia A Camperi
Nov 20, 2019·Minerva ginecologica·Papri SarkarAnthony N Imudia
Jan 6, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Valentina Di NisioSandra Cecconi
Apr 4, 2020·Zygote : the Biology of Gametes and Early Embryos·Kuo-Chung LanYi-Ru Tsai
May 6, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Maria Salomé Bezerra EspinolaCesare Aragona
Mar 27, 2018·Endocrinology·T Rajendra Kumar
Mar 9, 2021·Andrologia·Chara OraiopoulouAlexia Chatziparasidou
Jun 6, 2021·Reproductive Biology and Endocrinology : RB&E·Qigui XieRi-Cheng Chian

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