Ovarian stimulation protocols based on follicle-stimulating hormone glycosylation pattern: impact on oocyte quality and clinical outcome

Fertility and Sterility
Helmy SelmanImam El-Danasouri

Abstract

To evaluate the impact of follicle-stimulating hormone (FSH) with different glycosylation patterns on oocyte quality and clinical outcomes in an in vitro fertilization (IVF) treatment program. Prospective randomized, open-label, clinical study. Assisted reproduction center. One hundred eighty-eight infertile couples undergoing assisted fertilization treatment. All participants underwent a standard down-regulation with a gonadotropin-releasing hormone (GnRH) analogue. The patients were randomized into three groups: 63 patients received combined sequential acidic and less-acidic FSH, 65 patients received only less-acidic FSH (recombinant FSH), and 60 received only acidic FSH (human-derived FSH). Number of mature metaphase II oocytes, embryo quality, clinical pregnancy rates, and implantation rates. The pregnancy and implantation rates were statistically significantly lower in the less-acidic recombinant FSH alone group than in the combined sequential acidic hFSH/less-acidic recombinant FSH, and acidic hFSH alone groups (33.3%, 43.5%, 39% and 17.3%, 24.5%, 20.4%, respectively). Metaphase II oocytes and grade 1 embryos were statistically significantly higher in favor of the combined sequential acidic hFSH/less-acidic recombinant FS...Continue Reading

References

Jul 1, 1992·Journal of Reproduction and Fertility·P L Nayudu, S M Osborn
Jan 1, 1988·Annals of the New York Academy of Sciences·L L Veeck
May 1, 1985·Journal of Reproduction and Fertility·R M MoorI M Crosby
Nov 5, 2002·Fertility and Sterility·Helmy A SelmanImam El-Danasouri
Dec 10, 2002·Reproductive Biomedicine Online·Penelope L NayuduAlfredo Ulloa-Aguirre
Feb 7, 2003·Human Reproduction·Hesham Al-InanyGamal Serour

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Citations

Feb 26, 2013·Reproductive Biology and Endocrinology : RB&E·Yaakov BentovRobert F Casper
May 20, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hesham G Al-Inany, Ahmed M Abou-Setta
Oct 29, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alessandro PacchiarottiArianna Pacchiarotti
Jun 28, 2014·Molecular and Cellular Endocrinology·Livio CasariniManuela Simoni
Jun 21, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicola ColacurciPasquale De Franciscis
Jan 30, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sandro GerliGian Carlo Di Renzo
Feb 11, 2015·Molecular and Cellular Endocrinology·Viktor Y ButnevGeorge R Bousfield
Jun 22, 2017·Human Fertility : Journal of the British Fertility Society·Mariano Mascarenhas, Adam H Balen
Mar 29, 2020·International Journal of Molecular Sciences·Livio CasariniManuela Simoni

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