Ovarian suppression for adjuvant treatment of hormone receptor-positive early breast cancer.

The Cochrane Database of Systematic Reviews
Kim Tam BuiAnnabel Goodwin

Abstract

Approximately 80% of breast cancers amongst premenopausal women are hormone receptor-positive. Adjuvant endocrine therapy is an integral component of care for hormone receptor-positive breast cancer and in premenopausal women includes oestrogen receptor blockade with tamoxifen, temporary suppression of ovarian oestrogen synthesis by luteinising hormone releasing hormone (LHRH) agonists, and permanent interruption of ovarian oestrogen synthesis with oophorectomy or radiotherapy. Recent international consensus statements recommend single-agent tamoxifen or aromatase inhibitors with ovarian function suppression (OFS) as the current standard adjuvant endocrine therapy for premenopausal women (often preceded by chemotherapy). This review examined the role of adding OFS to another treatment (i.e. chemotherapy, endocrine therapy, or both) or comparing OFS to no further adjuvant treatment. To assess effects of OFS for treatment of premenopausal women with hormone receptor-positive early breast cancer. For this review update, we searched the Specialised Register of the Cochrane Breast Cancer Group, MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL; 2019, Issue 8), the World Health Organization (WHO) Internatio...Continue Reading

References

Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C I FalksonG Falkson
Jan 1, 1989·Hormone Research·M BaumP B Melhuish
Aug 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Ludwig Breast Cancer Study Group
Oct 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Castiglione-GertschJ Forbes
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S E RivkinC K Osborne
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J BinesM A Cobleigh
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O PaganiH J Senn
May 5, 2000·The Cochrane Database of Systematic Reviews·UNKNOWN Early Breast Cancer Trialists' Collaborative Group
Jul 25, 2000·The Cochrane Database of Systematic Reviews·UNKNOWN Early Breast Cancer Trialists' Collaborative Group
Sep 10, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J A SöreideS Kvinnsland
Dec 19, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W JonatUNKNOWN Zoladex Early Breast Cancer Research Association Study
Jan 17, 2003·Journal of the National Cancer Institute·Nicoletta ColomboUNKNOWN International Collaborative Ovarian Neoplasm (ICON) collaborators
May 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marianne NystedtLars Erik Rutqvist
Jul 31, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M KaufmannUNKNOWN Zoladex Early Breast Cancer Research Association (ZEBRA) Trialists' Group
Nov 12, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H de HaesUNKNOWN Zoladex Early Breast Cancer Research Association Trialists Group
Dec 18, 2003·Journal of the National Cancer Institute·UNKNOWN International Breast Cancer Study Group (IBCSG)Richard D Gelber
Jan 29, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R ArriagadaT Tursz
Jun 2, 2005·The Breast : Official Journal of the European Society of Mastology·Rohini SharmaAnne Hamilton
Aug 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy E DavidsonMartin D Abeloff
Feb 28, 2006·Breast Cancer Research and Treatment·Florian FitzalMichael Gnant
Mar 21, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M BaumUNKNOWN ZIPP International Collaborators Group
Jun 13, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gunter von MinckwitzManfred Kaufmann
Nov 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janice M WalsheSandra M Swain
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jürg BernhardUNKNOWN International Breast Cancer Study Group Trial VIII
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter SchmidKurt Possinger
Sep 28, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Manfred KaufmannUNKNOWN German Adjuvant Breast Cancer Study Group (GABG)
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 14, 2009·The New England Journal of Medicine·Michael GnantC Marth
Feb 27, 2009·Journal of the National Cancer Institute·Allan HackshawRichard Sainsbury
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Shom GoelJane Beith
Nov 11, 2011·The Cochrane Database of Systematic Reviews·Taryn Young, Sally Hopewell

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.