PMID: 2485204Jan 1, 1989Paper

Ovarian toxicity of benzo(a)pyrene and metabolites in mice

Reproductive Toxicology
D R MattisonP J Thomford

Abstract

The effect of intraovarian injection of benzo(a)pyrene (BP) or one of three metabolites: +7,8-oxide (7,8-O), (-)-dihydrodiol (DHD), and (+)-diol-epoxide-2 (DE2) on ovarian volume, weight, and follicle number was investigated in DBA/2N (D2), C57BL/6N (B6), and (DBA/2N x C57BL/6N)F1 (F1) mice. Female mice, 6 to 8 weeks old, were treated by injection into the right ovary with the indicated compound (10 micrograms in 1 microL DMSO). The left ovary was untreated. Two weeks following treatment both ovaries were removed, fixed in Bouin's medium, serially sectioned, and stained with hematoxylin and eosin. Right ovarian weight was decreased in D2 mice treated with BP (P less than 0.01 and DHD (P less than 0.01). Left ovarian weight was increased in D2 mice treated with DE2 (P less than 0.05). BP decreased right ovarian volume in D2 (P less than 0.01) and F1 (P less than 0.01) mice. 7,8-O decreased right ovarian volume in D2 mice (P less than 0.05). DHD decreased right ovarian volume in D2 (P less than 0.01) and F1 (P less than 0.05) mice. DE2 decreased right ovarian volume in D2 (P less than 0.01) and F1 (P less than 0.01) mice. Left ovarian volume was increased in B6 (P less than 0.01) and D2 (P less than 0.05) mice treated with DE2. T...Continue Reading

References

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Citations

Dec 21, 2011·Archives of Gynecology and Obstetrics·Thomas FreourPaul Barriere
Jan 1, 1991·Reproductive Toxicology·B J SmithD R Mattison
Oct 23, 2010·Journal of Toxicology and Environmental Health. Part a·Aramandla RameshMohammad S Niaz
Aug 6, 2010·Human Reproduction Update·C DechanetH Dechaud
Apr 25, 2013·Molecular Human Reproduction·Natalia M Grindler, Kelle H Moley
Nov 27, 2007·The Journal of Clinical Investigation·Andrea JurisicovaRobert F Casper
Mar 31, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·P PocarS Hombach-Klonisch
Sep 15, 2012·Toxicology and Applied Pharmacology·Tyler B MoranLori T Raetzman
Mar 1, 1991·Toxicology and Applied Pharmacology·D R Plowchalk, D R Mattison

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