PMID: 2492958Feb 1, 1989Paper

Ovarian transforming growth factor-beta (TGF beta): cellular site(s), and mechanism(s) of action

Molecular and Cellular Endocrinology
E Y AdashiD R Twardzik

Abstract

It is the objective of the experiments reported herein to examine the possible relevance of transforming growth factor-beta (TGF beta) to theca-interstitial cell function, and to further characterize the established interaction of TGF beta with the granulosa cell. In examining the interaction of TGF beta (10 ng/ml) with murine theca-interstitial cells, no significant effect was observed on either basal or human chorionic gonadotropin (hCG)-stimulated androsterone accumulation. In contrast, given murine granulosa cells, TGF beta (10 ng/ml) produced dose- and time-dependent augmentation of follicle-stimulating hormone (FSH)-supported aromatase activity with a minimal and median effective doses of 20 +/- 3 and 123 +/- 24 pg/ml, respectively and a minimal time requirement of less than or equal to 48 h. The ability of TGF beta to augment FSH hormonal action could not be accounted for by alteration(s) of specific FSH binding (13965 +/- 298 and 12614 +/- 694 cpm/4 X 10(5) cells for FSH and FSH + TGF beta). However, TGF beta proved capable of exerting a direct upregulatory effect on stimulatable adenylate cyclase activity, further enhancement occurring at site(s) distal to cAMP generation (dibutyryl cyclic AMP (Bt2cAMP) = 1.4 +/- 0.2 n...Continue Reading

References

Sep 14, 1986·Biochemical and Biophysical Research Communications·M KnechtK J Catt

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Citations

May 22, 2002·Biology of Reproduction·Jian XuElizabeth A McGee
Jun 5, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Jennifer L JuengelDouglas C Eckery
Feb 1, 2018·Journal of Animal Science·Cheyenne L RobinsonLeon J Spicer
Oct 1, 1994·Molecular Reproduction and Development·M M Shull, T Doetschman
Sep 22, 2000·The Journal of Biological Chemistry·F OtsukaS Shimasaki
Jul 12, 2001·The Journal of Biological Chemistry·F OtsukaS Shimasaki
Mar 25, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Xiaofeng ZhengPaul D Carrière
Jun 15, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiangmin LvCheng Wang
Sep 27, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Wendy V Ingman, Sarah A Robertson
Oct 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·E Y Adashi
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·O AvalletJ M Saez

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