Ovarian tumors of low malignant potential. Correlation of DNA index and S-phase fraction with histopathologic grade and clinical outcome

Cancer
D DemirelI Ramzy

Abstract

DNA ploidy and/or S-phase fraction have been used as biologic predictors of aggressive behavior in a variety of solid tumors, including ovarian carcinomas. Recently, attention has focused on borderline lesions to determine if flow cytometry plays a role in separating potentially aggressive tumors from those which will pursue a more innocuous course. Paraffin-embedded tissue from 42 tumors with low malignant potential (LMP) were analyzed by flow cytometry (FC) to determine the DNA index (DI) and S-phase fraction (SPF). These result were then correlated with conventional pathologic parameters (size, nuclear grade, architecture, and mitotic index) and with clinical parameters (stage and age). Statistical analysis was carried out using the Fisher's Exact and Kruskal-Wallis tests. Thirty-five cases (83.3%) were diploid, while 7 cases (16.7%) showed aneuploid stemlines, with a mean DI of 1.2 (range: 1.1-1.4). The mean SPF was 3.5% for the diploid tumors and 4.5% for the aneuploid tumors. Serous tumors comprised 74% of our cases; the remainder were either mucinous or endometrioid tumors. Complex solid architectural patterns were found in 29 tumors whereas high nuclear grade was seen in 24. A mitotic rate (MR) of 0-3/10 high power fiel...Continue Reading

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Citations

Oct 11, 2005·BMC Cancer·Maja KrasevicNeda Smiljan-Severinski
May 15, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M AkesonG Horvath
Feb 9, 2008·Pharmacology·Howard R Mellor, Richard Callaghan
Feb 8, 2005·Histopathology·H Fox
Mar 17, 2005·Journal of Cutaneous Pathology·Raymond L BarnhillMarianne Berwick
Jun 2, 2006·Cancer Genetics and Cytogenetics·Lovisa OsterbergGyörgy Horvath
Oct 19, 2011·Journal of Skin Cancer·Daniela Göppner, Martin Leverkus
Jun 9, 2016·Open Access Macedonian Journal of Medical Sciences·Amina A Gamal El DinNermeen M Shaffie

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International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
J KaernE.O. Pettersen
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