PMID: 9191114Jun 1, 1997Paper

Ovariectomy and estradiol treatment affect the dopamine transporter and its gene expression in the rat brain

Brain Research. Molecular Brain Research
R BosséThérèse Di Paolo

Abstract

The impact of gonadal hormone withdrawal and estrogen therapy was investigated on the rat dopamine transporter (DAT). Short-term ovariectomized (ST-OVX, 2 weeks) and long-term ovariectomized (LT-OVX, 3 months) rats were treated or not with 17beta-estradiol (E2) for 2 weeks. DAT mRNA expression was measured by in situ hybridization in the substantia nigra pars compacta (SNc) for the nigrostriatal pathway and the ventral tegmental area (VTA) for the mesolimbic pathway whereas DAT levels were assessed by [3H]GBR-12935 autoradiography, respectively, in the striatum and the nucleus accumbens. Ovariectomy produced a time-dependent decrease of the DAT density in the striatum and the nucleus accumbens and the E2 treatment did not significantly restore these DAT levels. Neither ST-OVX nor E2 treatment of the ST-OVX animals altered the DAT mRNA expression in the SNc and the VTA. However, LT-OVX animals showed increased DAT mRNA levels in these regions. E2 treatment of LT-OVX animals partially restored DAT mRNA levels in the SNc and left these levels unchanged in the VTA. These opposite variations induced by OVX on the DAT density and their mRNA levels suggest the involvement of non-genomic mechanisms, such as post-transcriptional events ...Continue Reading

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Citations

May 24, 2003·Comprehensive Psychiatry·Miki BlochDavid R Rubinow
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Cathy VaillancourtThérèse Di Paolo
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·J B Becker
Dec 5, 1998·Brain Research. Molecular Brain Research·E Küppers, C Beyer
Dec 10, 1999·Epilepsy Research·D P Figlewicz
Sep 2, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kristina A UbanLiisa A M Galea
Feb 17, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tomás PálenícekJirí Horácek
Feb 16, 2008·Pharmacology, Biochemistry, and Behavior·Sarah L ParylakCynthia M Kuhn
Oct 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·M MorissetteT Di Paolo
Nov 18, 2006·Neuroscience and Biobehavioral Reviews·Kelly Allott, Jennifer Redman
Dec 31, 2008·Journal of Neuroscience Research·Marc Morissette, Thérèse Di Paolo
Feb 3, 2006·Journal of Neuroendocrinology·M Le Saux, T Di Paolo
May 21, 2008·Journal of Neurochemistry·Rebecca A AlyeaCheryl S Watson
Jun 19, 2010·CNS Neuroscience & Therapeutics·Maria Gabriela SánchezThérèse Di Paolo
Jul 17, 2013·Climacteric : the Journal of the International Menopause Society·N PluchinoA R Genazzani
Oct 1, 2011·Hormone Molecular Biology and Clinical Investigation·Andrea Riccardo GenazzaniNicola Pluchino
Sep 30, 2014·CNS Spectrums·Crystal Edler SchillerDavid R Rubinow
Feb 9, 2000·Frontiers in Neuroendocrinology·B M SchmidtM Wehling
Dec 1, 2009·Neurotoxicology and Teratology·Steven L NeeseSusan L Schantz
Feb 23, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Joy SimpsonJohn P Kelly
Oct 20, 2005·Physiology & Behavior·T PalenicekJ Horacek

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