Ovariectomy in the developing rat decelerates cortical spreading depression in adult brain

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Noranege Epifânio AcciolyRubem Carlos Araujo Guedes

Abstract

The brain of mammals is one important target organ for the action of gonadal steroids and, when occurring during development, this hormonal influence may result in important repercussion on the brain electrophysiological properties at adulthood, some of which depending on the brain excitability. Here we have characterized in early-ovariectomized adult rats the brain ability to propagate the excitability-related phenomenon known as cortical spreading depression (CSD), as an index of the cerebral electrophysiological effects of the early-induced absence of the ovarian hormones. Wistar female rat pups (7-day old) underwent bilateral ovariectomy (Ovx group; n=21) or Sham surgery (Sham group; n=22), or no surgery (Naive group; n=22). When the pups became adult (90-130 days), they were submitted to the recording of CSD (electrocorticogram and slow DC-voltage variation) in two points of the cortical surface during 4h. Compared with both Naïve and Sham controls, bilateral ovariectomy early in life resulted in significantly higher body weights (from days 50-65 onwards) and severely reduced uterus weights at adulthood. Furthermore, in the Ovx animals the amplitudes and durations of the DC-potential changes of CSD were higher, and the CSD...Continue Reading

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Citations

Jan 1, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cássia Borges LimaRubem Carlos Araujo Guedes
Dec 29, 2015·Journal of Applied Animal Welfare Science : JAAWS·Marlena C Kruger, Patrick C H Morel
Jan 27, 2018·Oncotarget·Alexander J SandweissTally M Largent-Milnes

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