Ovariectomy Induces Microglial Cell Activation and Inflammatory Response in Rat Prefrontal Cortices to Accelerate the Chronic Unpredictable Stress-Mediated Anxiety and Depression.

BioMed Research International
Fei GeJing Yan

Abstract

Perimenopausal women are associated with increased risks of depression and anxiety, which may be potentially related to the lack of ovarian hormone with antidepression activity in the body. However, the precise mechanism remains unclear so far. This study first adopted the Sprague-Dawley (SD) female rats to construct the ovariectomy (OVX) combined with a chronic unpredictable stress (CUS) model. Then, a series of behavioral experimental results revealed that the ovariectomized rats receiving CUS had remarkably elevated anxiety and depression behaviors relative to those in sham group rats, and the sucrose preference rate in the sucrose preference test (SPT) was evidently reduced. In elevated plus maze test (EPM) experiment, the open arm entry time and open arm duration were decreased. In the open field test (OFT), the number of line crossings, rearing number, center square entries, and center square duration were reduced; the grooming time was extended; and the number of fecal particles in rats was increased. In the forced swimming test (FST), the rat immobility rate was increased, while the numbers of swimming and crawling were decreased. Afterwards, we discovered that OVX downregulated the serum levels of estradiol and cortico...Continue Reading

References

Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·J K HarrisonL Feng
Nov 26, 1999·Archives of Medical Research·L Martínez-MotaM Saavedra
Feb 7, 2002·JAMA : the Journal of the American Medical Association·Mark A HlatkyUNKNOWN Heart and Estrogen/Progestin Replacement Study (HERS) Research Group
Aug 21, 2002·Stress : the International Journal on the Biology of Stress·Victoria Luine
Mar 3, 2004·Annals of the New York Academy of Sciences·Hanna OstlundYasmin L Hurd
Aug 30, 2005·Neuroscience·C DallaZ Papadopoulou-Daifoti
Apr 5, 2007·Nature Protocols·Alicia A Walf, Cheryl A Frye
Jul 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katsunori SasaharaKazuyoshi Tsutsui
Aug 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony LyonsMarina A Lynch
Feb 21, 2008·Glia·Amanda SierraKaren Bulloch
Jan 27, 2009·Menopause : the Journal of the North American Menopause Society·Joanne RyanLorraine Dennerstein
Feb 27, 2009·Fertility and Sterility·Tiffany LoveJon-Kar Zubieta
May 26, 2009·Menopause International·Alessandra Graziottin, Audrey Serafini
Apr 14, 2010·The Psychiatric Clinics of North America·Claudio N Soares, Benicio N Frey
Jun 10, 2010·Menopause : the Journal of the North American Menopause Society·Ellen W Freeman
Jun 29, 2010·Primary Care Companion to the Journal of Clinical Psychiatry·Anita H Clayton, Philip T Ninan
Jul 10, 2010·Menopause : the Journal of the North American Menopause Society·Susan G KornsteinA John Rush
Jul 28, 2010·Behavioural Pharmacology·Sonali LokugeMeir Steiner
Jan 29, 2011·Journal of Affective Disorders·Fiona K JuddChristina Bryant
Nov 2, 2011·Brain, Behavior, and Immunity·F Fionnuala CoxMarina A Lynch
Mar 15, 2012·Menopause : the Journal of the North American Menopause Society·Laura A ColangeloSusan M Gapstur
Apr 28, 2012·Brain Research Bulletin·Yanqing BianBaohua Zhao
Jun 19, 2013·Neurochemistry International·Jelena Zlatković, Dragana Filipović
Oct 30, 2013·Molecular Psychiatry·A F SchatzbergG M Murphy
Jan 20, 2015·Molecular Neurobiology·Yu Tang, Weidong Le
Jul 26, 2016·Frontiers in Endocrinology·Erica de Almeida Duque, Carolina Demarchi Munhoz
Jul 28, 2016·Nature Neuroscience·Richard M Ransohoff
Sep 8, 2016·Biological Psychiatry·Jennifer B Dwyer, David A Ross
Oct 30, 2016·Behavioural Brain Research·Bhanu Chandra KarisettySumana Chakravarty
Feb 6, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mamoru Shibata, Norihiro Suzuki
Sep 26, 2017·Frontiers in Cellular Neuroscience·Gaurav Singhal, Bernhard T Baune

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

Image
Pro Plus
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
R A PowerT J Wronski
Journal of Biomedical Materials Research
Y OkamotoS Y Liu
© 2022 Meta ULC. All rights reserved