Ovary and uterus transplantation

Reproduction : the Official Journal of the Society for the Study of Fertility
Roger G Gosden

Abstract

Ovarian and uterine transplantation are procedures gaining more attention again because of potential applications in respectively fertility preservation for cancer and other patients and, more tentatively, women with uterine agenesis or hysterectomy. Cryopreservation of tissue slices, and possibly whole organs, is providing opportunities for banking ovaries for indefinite periods before transplanting them back to restore fertility. The natural plasticity of this organ facilitates grafting to different sites where they can be revascularized and rapidly restore the normal physiology of secretion and ovulation. Ischemic damage is a chief limitation because many follicles are lost, at least in avascular grafts, and functional longevity is reduced. Nevertheless, grafts of young ovarian tissue, even after cryopreservation, can be highly fertile in laboratory rodents and, in humans, autografts have functioned for up to 3 years before needing replacement. Transplantation by vascular anastomosis provides potentially longer function but it is technically much more demanding and riskier for the recipient. It is the only practicable method with the uterus, and has enabled successful pregnancies in several species, but not yet in humans. Co...Continue Reading

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Citations

Mar 14, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Cansu AgcaYuksel Agca
Jun 10, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Fengyin LiShixian Zhou
Dec 17, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·R A Anderson
May 23, 2014·Annual Review of Biomedical Engineering·Lonnie D SheaAriella Shikanov
Jun 5, 2012·Fertility and Sterility·Michael GrynbergNelly Frydman
May 18, 2011·Clinical Endocrinology·Richard A Anderson, W Hamish B Wallace
Sep 9, 2015·Human Reproduction·Kazuhiro KawamuraAaron J Hsueh
Oct 26, 2013·Reproduction, Fertility, and Development·Jianan LiuFrederick G Silversides
Mar 25, 2017·Biology of Reproduction·Xiaofei SunTony DeFalco
Mar 28, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Benjamin Fisch, Ronit Abir
Jan 16, 2018·Reproduction, Fertility, and Development·N J DonfackA P R Rodrigues

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