Ovary-independent estrogen receptor expression in neonatal porcine endometrium

Biology of Reproduction
B J TarletonF F Bartol

Abstract

Effects of age and ovariectomy (OVX) at birth on uterine growth, endometrial development, and estrogen receptor (ER) expression were determined for intact and OVX gilts (n = 5 per day) hysterectomized on postnatal days (PND) 0, 15, 30, 60, 90, or 120. Uteri were evaluated histologically, and ER protein and mRNA expression were characterized immunohistochemically and by in situ hybridization. OVX did not affect uterine weight or endometrial thickness until after PND 60, when both increased more rapidly in intact gilts. Neither did it affect genesis of uterine glands, which were present and which proliferated after PND 0, or endometrial ER expression patterns in glandular epithelium (GE), luminal epithelium (LE), or stroma (S) between PND 0 and 120. Endometrium was ER negative at birth. On PND 15, the ER signal was strong in GE, weak in S, and effectively absent in LE. Thereafter, although the ER signal remained strong in GE and increased through PND 60 in S, it was not evident consistently until after PND 30 in LE. The data indicate that 1) porcine uterine growth and endometrial morphogenesis are ovary-independent processes before PND 60; 2) uterine gland genesis is associated temporally with development of ER-positive endometri...Continue Reading

Citations

Aug 24, 2000·Molecular Reproduction and Development·C A GrayT E Spencer
Apr 27, 2013·Molecular Human Reproduction·Paul S CookeKanako Hayashi
Feb 28, 2003·Biology of Reproduction·Becky J TarletonFrank F Bartol
Apr 18, 2003·Biology of Reproduction·Karen D CarpenterThomas E Spencer
Dec 25, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Joseph C ChenCarol A Bagnell
Feb 29, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Wenbo YanCarol A Bagnell
May 5, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Wenbo YanCarol A Bagnell
Mar 13, 2016·Animal Reproduction Science·Sang-Hee LeeChoon-Keun Park
Jun 16, 2005·Annals of the New York Academy of Sciences·Wenbo YanCarol A Bagnell
Jun 16, 2005·Annals of the New York Academy of Sciences·Carol A BagnellFrank F Bartol
May 7, 2009·Annals of the New York Academy of Sciences·Frank F BartolCarol A Bagnell
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·F F BartolC A Bagnell
Aug 4, 2009·Reproduction in Domestic Animals = Zuchthygiene·K Knapczyk-StworaM Slomczynska
Jul 4, 2006·Ultrasonics·S de la Fuente-BlancoJ A Gallego-Juárez
Oct 20, 2011·Molecular and Cellular Endocrinology·Thomas E SpencerJustyna Filant
Oct 29, 2011·Molecular and Cellular Endocrinology·Frank F Bartol, Carol A Bagnell
Apr 14, 2017·Molecular Reproduction and Development·Carol A BagnellFrank F Bartol
May 23, 2001·Biology of Reproduction·C A GrayT E Spencer
Sep 6, 2018·Annual Review of Animal Biosciences·Thomas E SpencerFrank F Bartol
Oct 24, 2001·Biology of Reproduction·C A GrayT E Spencer
Dec 4, 2015·Biology of Reproduction·Kathleen M RahmanCarol A Bagnell
Apr 3, 2004·Endocrinology·Kanako HayashiThomas E Spencer
May 11, 2019·Endocrine Reviews·Andrew M KelleherThomas E Spencer
Oct 27, 2012·Journal of Animal Science·F F BartolC A Bagnell
Jan 22, 2000·Biology of Reproduction·C Allison GrayT E Spencer
Jul 9, 2005·Journal of Biochemistry·Yan Yin, Liang Ma

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