Over-diagnosis and under-diagnosis of screen- vs non-screen-detected prostate cancers with in men with prostate-specific antigen levels of 2.0-10.0 ng/mL

BJU International
Alexandre E PelzerWolfgang Horninger

Abstract

To evaluate possible over- and under-diagnosis of prostate cancer in a screened vs a referral population in the same range of prostate-specific antigen (PSA). In all, 1445 patients undergoing radical prostatectomy and with a PSA level of <10 ng/mL were evaluated; 237 were from outside Tyrol (Austria) and represented the unscreened group, and 1208 were Tyrolean screening volunteers. Over-diagnosis was defined as a pathological stage of pT2a and a Gleason score of <7 with no positive surgical margins. Under-diagnosis was defined as a pathological stage of >or=pT3a or positive surgical margins. The chi-square test was used to assess the differences, with P < 0.05 considered to indicate statistical significance. There were no significant differences in patient age or PSA levels between the study groups. There was over-diagnosis in the screening and referral groups in 17.4% and 8.9%, respectively, and under-diagnosis in 18.6% and 42.2%, respectively. This study suggests that patients with prostate cancer participating in a screening programme are less likely to be under-diagnosed or have extracapsular disease than their counterparts in a referral population, even in the same PSA range, after radical prostatectomy. Furthermore, there...Continue Reading

References

Feb 2, 1994·JAMA : the Journal of the American Medical Association·J I EpsteinC B Brendler
May 11, 1999·JAMA : the Journal of the American Medical Association·C R PoundP C Walsh
Feb 24, 2001·Controlled Clinical Trials·J K GohaganUNKNOWN Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Project Team
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Harry J de KoningUNKNOWN International Prostate Cancer Screening Trials Evaluation Group
Jul 4, 2002·Journal of the National Cancer Institute·Ruth EtzioniEric J Feuer
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
May 15, 2007·The Journal of Urology·Alexandre E PelzerWolfgang Horninger
May 15, 2007·The Journal of Urology·Theresa GraifWilliam J Catalona

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