Abstract
FEZ family zinc finger 1 (FEZF1) is an essential transcription factor during olfactory development. In gastrointestinal tumors, FEZF1 plays an oncogenic role through DNA demethylation. However, the role of FEZF1 in the prognosis of human glioma prognosis remains unclear. In this research, we discovered that FEZF1 was significantly increased in glioma tissues in contrast to normal brain tissues (NBTs; P < 0.05). Moreover, the expression of FEZF1 showed a significant correlation with Eastern Cooperative Oncology Group performance status, World Health Organization grade, isocitrate dehydrogenase 1 mutation, over-expression of glial fibrillary acidic protein and 1p19q co-deletion. Furthermore, a high level of FEZF1 in patients with glioma acted as an independent biomarker to predict reduced survival (P = 0.026). In an in vitro experiment, FEZF1 can promote the proliferation, migration, and invasion of glioma cells and inhibit cell apoptosis by activating Akt-ERK pathway. All these findings suggest that FEZF1 acts as a key oncogene and predicts a poor prognosis in glioma.
References
May 12, 2007·Expert Review of Anticancer Therapy·Marta Penas-Prado, Mark R Gilbert
Feb 21, 2009·The New England Journal of Medicine·Hai YanDarell D Bigner
Mar 26, 2009·Cancer Research·In-Sung SongNam-Soon Kim
Oct 23, 2009·Acta Neuropathologica·Werner Paulus
Dec 21, 2010·International Journal of Cancer. Journal International Du Cancer·In-Sung SongNam-Soon Kim
Apr 1, 2011·The Journal of Comparative Neurology·Matthew J EcklerBin Chen
Sep 6, 2014·American Journal of Human Genetics·L Damla KotanA Kemal Topaloglu
Feb 24, 2015·Journal of Cancer Research and Clinical Oncology·Yibing ChenShiming He
Jun 11, 2015·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkJianan Zhang
May 30, 2016·Cancer Medicine·Giovanni MarfiaRolando Campanella
Jul 3, 2016·Journal of Molecular Neuroscience : MN·Zhuo XiYunhui Liu
Jun 28, 2017·Molecular Cancer·Mingjun YuYunhui Liu
Jul 22, 2017·Oncology Reports·Fanjun MengZhiyu Wang
Sep 16, 2017·Biochimie·Yunhu YuFei Wang
Mar 10, 2018·Oncogene·Yuan-Yuan LiuCong Cao
Citations
Nov 22, 2018·Journal of Neuro-oncology·Zhong LiuXiaosi Han
Jul 10, 2019·Journal of Ophthalmology·Yong WangShuyan Gu
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Tianyu ZouCheng Mei
Dec 19, 2020·Journal of Cellular and Molecular Medicine·Mingjun YuShijia Yu
Nov 20, 2021·Journal of Neuro-oncology·Kang YangJian Yin