Over-Expressed FEZF1 Predicts a Poor Prognosis in Glioma and Promotes Glioma Cell Malignant Biological Properties by Regulating Akt-ERK Pathway

Journal of Molecular Neuroscience : MN
Mingjun YuYunhui Liu

Abstract

FEZ family zinc finger 1 (FEZF1) is an essential transcription factor during olfactory development. In gastrointestinal tumors, FEZF1 plays an oncogenic role through DNA demethylation. However, the role of FEZF1 in the prognosis of human glioma prognosis remains unclear. In this research, we discovered that FEZF1 was significantly increased in glioma tissues in contrast to normal brain tissues (NBTs; P < 0.05). Moreover, the expression of FEZF1 showed a significant correlation with Eastern Cooperative Oncology Group performance status, World Health Organization grade, isocitrate dehydrogenase 1 mutation, over-expression of glial fibrillary acidic protein and 1p19q co-deletion. Furthermore, a high level of FEZF1 in patients with glioma acted as an independent biomarker to predict reduced survival (P = 0.026). In an in vitro experiment, FEZF1 can promote the proliferation, migration, and invasion of glioma cells and inhibit cell apoptosis by activating Akt-ERK pathway. All these findings suggest that FEZF1 acts as a key oncogene and predicts a poor prognosis in glioma.

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Citations

Nov 17, 2020·Frontiers in Cell and Developmental Biology·Tianyu ZouCheng Mei
Dec 19, 2020·Journal of Cellular and Molecular Medicine·Mingjun YuShijia Yu

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Methods Mentioned

BETA
histone acetylation
electrophoresis
Transfection

Software Mentioned

FLuor Chem2

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