Jul 16, 1990

Over-expression of facilitative glucose transporter genes in human cancer

Biochemical and Biophysical Research Communications
T YamamotoH Imura

Abstract

The expression of five facilitative glucose transporter genes, GLUT1 (erythrocyte type), GLUT2 (liver type), GLUT3 (brain type), GLUT4 (muscle/fat type), and GLUT5 (small intestine type), was examined in human cancer tissues of the digestive system by RNA blotting analysis. The amounts of the GLUT1, GLUT2, and GLUT3 transcripts were elevated in most cancer tissues studied, although the expression of the GLUT2 gene is primarily restricted to the liver. On the other hand, mRNA levels of GLUT4 and GLUT5 were below sensitivity in all cancer tissues examined. These results suggest that over-expression of GLUT1 and GLUT3 might be closely related with tissue development and that the acceleration of glucose uptake by transformed cells may result, at least in part, from the increase in the expression of these two glucose transporters.

  • References5
  • Citations197

References

Mentioned in this Paper

Gene Expression Regulation, Neoplastic
Hexose Transporter
RNA, Neoplasm
SLC2A2
SLC2A1
Poly(A) Tail
Malignant Neoplasms
Cancer of Digestive System
SLC2A3

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