Over-expression of RPL23 in myelodysplastic syndromes is associated with apoptosis resistance of CD34+ cells and predicts poor prognosis and distinct response to CHG chemotherapy or decitabine

Annals of Hematology
Lingyun WuYan Zhang

Abstract

Ribosomal protein (RP) L23 has been suggested to be a negative regulator of cell apoptosis. In the present study, we analyzed RPL23 expression in 169 patients with myelodysplastic syndrome (MDS) by using real-time PCR. The apoptosis of CD34(+) marrow cells was examined by flow cytometry, and the correlation between RPL23 expression levels and apoptosis in CD34(+) cells was assessed. We then analyzed the clinical significance of RPL23 expression for predicting disease progression and patient survival as well as therapeutic response in patients administered with a cytarabine, homoharringtonine, and G-CSF (CHG) regimen or decitabine therapy. Increased RPL23 expression was found in patients with higher-risk MDS than in patients with lower-risk disease (p = 0.004). RPL23 expression levels were found being inversely correlated with decreased apoptotic ratio of CD34(+) cells in higher-risk patients (r = -0.672, p < 0.001). Compared to patients with normal RPL23 expression levels, those with increased RPL23 expression presented higher rates of transformation to acute myeloid leukemia (p = 0.005) and reduced 2-year survival rates (p = 0.012). Multivariate regression analysis showed that RPL23 expression level was an independent predicto...Continue Reading

References

Feb 1, 1987·American Journal of Clinical Pathology·F DelacrétazJ Costa
Sep 21, 2000·British Journal of Haematology·S PoulainP Fenaux
Aug 18, 2004·Molecular and Cellular Biology·Aiwen JinYanping Zhang
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lilia SuárezAlberto Orfao
May 10, 2008·Blood·Stephen D Nimer
Jan 23, 2009·Nature Cell Biology·Michael WanzelMartin Eilers
Apr 14, 2009·Molecular Cell·Jonathan R Warner, Kerri B McIntosh
Jun 17, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David P SteensmaHagop Kantarjian

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Citations

Nov 13, 2018·Journal of Cellular Physiology·Ghader MolaviElaheh Zadeh Hosseingholi
Jul 25, 2019·Cellular and Molecular Life Sciences : CMLS·Shannon E WeeksRajeev S Samant
Mar 20, 2018·Brain, Behavior, and Immunity·Annesa FlentjeBradley E Aouizerat

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