Abstract
Ribosomal protein (RP) L23 has been suggested to be a negative regulator of cell apoptosis. In the present study, we analyzed RPL23 expression in 169 patients with myelodysplastic syndrome (MDS) by using real-time PCR. The apoptosis of CD34(+) marrow cells was examined by flow cytometry, and the correlation between RPL23 expression levels and apoptosis in CD34(+) cells was assessed. We then analyzed the clinical significance of RPL23 expression for predicting disease progression and patient survival as well as therapeutic response in patients administered with a cytarabine, homoharringtonine, and G-CSF (CHG) regimen or decitabine therapy. Increased RPL23 expression was found in patients with higher-risk MDS than in patients with lower-risk disease (p = 0.004). RPL23 expression levels were found being inversely correlated with decreased apoptotic ratio of CD34(+) cells in higher-risk patients (r = -0.672, p < 0.001). Compared to patients with normal RPL23 expression levels, those with increased RPL23 expression presented higher rates of transformation to acute myeloid leukemia (p = 0.005) and reduced 2-year survival rates (p = 0.012). Multivariate regression analysis showed that RPL23 expression level was an independent predicto...Continue Reading
References
Feb 1, 1987·American Journal of Clinical Pathology·F DelacrétazJ Costa
Nov 5, 1997·British Journal of Haematology·E WattelP Fenaux
Sep 21, 2000·British Journal of Haematology·S PoulainP Fenaux
Aug 30, 2002·Leukemia·M OosterveldUNKNOWN EORTC, EBMT, SAKK, GIMEMA Leukemia Groups and the MD Anderson Cancer Center
May 20, 2004·Experimental Cell Research·Yongquan ShiDaiming Fan
Aug 18, 2004·Molecular and Cellular Biology·Mu-Shui DaiHua Lu
Aug 18, 2004·Molecular and Cellular Biology·Aiwen JinYanping Zhang
Oct 16, 2004·International Journal of Hematology·Xiao LiH Joachim Deeg
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lilia SuárezAlberto Orfao
Mar 29, 2006·Experimental and Molecular Pathology·Morito KurataMasanobu Kitagawa
Apr 13, 2006·Blood·Bruce D ChesonHagop Kantarjian
Jun 23, 2006·Leukemia·J JinW-L Xu
May 10, 2008·Blood·Stephen D Nimer
Jan 23, 2009·Nature Cell Biology·Michael WanzelMartin Eilers
Apr 14, 2009·Molecular Cell·Jonathan R Warner, Kerri B McIntosh
May 21, 2009·European Journal of Clinical Investigation·P Valent, H-P Horny
Jun 17, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David P SteensmaHagop Kantarjian
Aug 13, 2009·Leukemia & Lymphoma·Lingyun WuQuan Pu
Oct 6, 2009·Blood·Kunju SridharPeter L Greenberg
Jun 28, 2011·Leukemia·K P NgY Saunthararajah
Aug 17, 2011·Journal of Cancer Research and Clinical Oncology·Lingyun WuQuan Pu
Citations
Aug 29, 2014·Medicinal Research Reviews·Wei WangRuiwen Zhang
Apr 2, 2015·Gene·Sora JinChunghee Cho
Jun 12, 2016·Gene·Fedor KryukovRoman Hajek
Nov 13, 2018·Journal of Cellular Physiology·Ghader MolaviElaheh Zadeh Hosseingholi
Sep 1, 2016·Pediatric Blood & Cancer·Pornpun SripornsawanYoshifumi Kawano
Jun 14, 2016·Science China. Life Sciences·Xilong XuYi Sun
Jul 25, 2019·Cellular and Molecular Life Sciences : CMLS·Shannon E WeeksRajeev S Samant
May 26, 2017·Scientific Reports·Yuekun QiLingyun Wu
Sep 14, 2018·Nature Communications·Brett M StevensCraig T Jordan
Feb 2, 2021·Frontiers in Microbiology·Jiawen LiQiuying Pang
Mar 20, 2018·Brain, Behavior, and Immunity·Annesa FlentjeBradley E Aouizerat