Over-the-counter analgesics and risk of ovarian cancer

Lancet
Daniel W CramerE R Greenberg

Abstract

Evidence that aspirin and other non-steroidal anti-inflammatory drugs reduce risk for colorectal cancer has prompted interest in their ability to prevent other cancers. We aimed to find out what effect over-the-counter analgesics have on risk of ovarian cancer. In a case-control study we compared use of over-the-counter analgesics by 563 women from eastern Massachusetts and New Hampshire, USA, who had epithelial ovarian cancer with 523 women from the general population. We calculated exposure odds ratios to estimate the effect of over-the-counter analgesics on ovarian cancer risk. Use of over-the-counter analgesics was assessed through interviews and defined as use at least once a week continuously for at least 6 months. The odds ratio for risk of ovarian cancer for aspirin use was 0.75 (95% CI 0.52-1.10), that for ibuprofen was 1.03 (0.64-1.64), and that for paracetamol was 0.52 (0.31-0.86), after adjusting for age, study centre, education, religion, parity, oral contraceptive use, and menstrual, arthritic, or headache pain. Relative to no use, the lower risk of ovarian cancer associated with paracetamol was more apparent for use on a daily basis, 0.39 (0.21-0.74), for more than 10 years of use, 0.40 (0.19-0.88), or for more t...Continue Reading

References

Dec 15, 1991·The New England Journal of Medicine·M J ThunC W Heath
May 25, 1991·Biochemical and Biophysical Research Communications·T A Santa-ColomaL E Reichert
Oct 1, 1994·Cancer·J E MuscatE L Wynder
Feb 28, 1994·Archives of Internal Medicine·I I PelegC M Wilcox
Mar 1, 1994·Epidemiology·D M Schreinemachers, R B Everson

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Citations

Jul 7, 2000·Seminars in Surgical Oncology·C H Holschneider, J S Berek
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D W CramerL Titus-Ernstoff
Dec 26, 2007·Pathology Oncology Research : POR·Bing XinHideki Mizunuma
Mar 21, 2009·Cancer Causes & Control : CCC·Eva LundinAnnekatrin Lukanova
Apr 21, 2010·Cancer Metastasis Reviews·Andrea TinelliVito Lorusso
Feb 10, 2007·Current Oncology Reports·Maria Rosaria Raspollini, Gian Luigi Taddei
Dec 14, 2011·Pathology Oncology Research : POR·Maria KoutsakiDemetrios A Spandidos
Apr 13, 2011·Genes & Nutrition·Mi-Kyung KimYong Sang Song
Sep 24, 2004·Gynecologic Oncology·Gabriella FerrandinaGiovanni Scambia
Oct 18, 2002·Obstetrics and Gynecology·Janet G Drake, Jeanne L Becker
Feb 15, 2002·Lancet·Kenneth F Schulz, David A Grimes
Sep 10, 2003·Hematology/oncology Clinics of North America·Gustavo Rodriguez
Sep 5, 2003·Journal of Clinical Epidemiology·Loren LipworthJørgen H Olsen
Aug 2, 2001·Internal Medicine Journal·D McGaw, R Harper
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·J RüschoffR Fishel
Jul 11, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Deodutta RoySatya Narayan
Dec 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R M Botting
Dec 25, 2003·American Journal of Epidemiology·Luis Alberto García Rodríguez, Sonia Hernández-Díaz
Feb 19, 2005·American Journal of Epidemiology·Kathryn L TerryDaniel W Cramer
Apr 4, 2009·American Journal of Epidemiology·Simone P PinheiroSusan E Hankinson
Sep 2, 1999·Journal of the National Cancer Institute·R B Ness, C Cottreau
Feb 21, 2002·Journal of the National Cancer Institute·Michael J ThunCarlo Patrono
Feb 19, 2004·Journal of the National Cancer Institute·Ellen T ChangNancy E Mueller
Feb 24, 2006·Current Opinion in Obstetrics & Gynecology·Katherine D Crew, Alfred I Neugut
May 16, 2009·Cancer Nursing·Monica R McLemoreMarylin J Dodd
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J S LeeK W Min
Mar 25, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Margaret A GatesSusan E Hankinson
Feb 10, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anna E PrizmentKristin E Anderson
Jun 6, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Veronica Wendy SetiawanMarc T Goodman
Mar 29, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Haim A AbenhaimDaniel W Cramer
Feb 23, 2011·International Journal of Molecular Sciences·Wei LiLing-Yun Zhai
Jan 14, 2005·Southern Medical Journal·Andrew J WeaverKaren G Costa
May 23, 2014·Journal of the National Cancer Institute·Louise BaandrupSusanne K Kjaer
Jul 15, 2006·Cancer Causes & Control : CCC·Cristina BosettiCarlo La Vecchia
Jun 12, 2004·American Journal of Epidemiology·Niccole R Sivak-SearsMargaret Wrensch
Dec 17, 2005·Epidemiology·Joellen M SchildkrautAndrew Berchuck

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