Over-the-scope-clip applications for perforated peptic ulcer

Surgical Endoscopy
Jing-Jing WeiZe-Hao Zhuang

Abstract

To investigate the effectiveness of over-the-scope-clip (OTSC)-based endoscopic closure in patients with perforated peptic ulcer (PPU). One hundred six patients diagnosed with PPU were treated with either OTSC (n = 26) or conservative treatments (n = 80), respectively. The outcome assessments included technical success rate, clinical success rate, post-treatment complications after 1 month, mortality rate, time to resume oral feeding, length of hospital stay, and the administration of antibiotics. In the OTSC group, technical and clinical success was achieved in 100% of patients without any complications, including death, incomplete closure, duodenal obstruction, and gastrointestinal bleeding, with a median operation time of 10 min. All patients in the OTSC group were discharged, while the mortality rate in the control group was 13.8%. Subsequent surgeries were required in 30% of patients in the control group. The median times to resume oral feeding were 3.5 (interquartile range [IQR] 2.0-5.25) days in the OTSC group and 7.0 (IQR 5.0-9.0) days in the control group (p < 0.001). One month post-procedure, 30% (24/80) of patients in the control group and 0 (0/26) in the OTSC group required additional operations (p < 0.001). No sign...Continue Reading

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Citations

Jul 14, 2020·World Journal of Gastroenterology : WJG·Nicholas BartellShivangi Kothari
May 13, 2020·Surgical Endoscopy·Carlos Robles-MedrandaHannah Pitanga-Lukashok
Mar 7, 2020·Current Problems in Surgery·Alice WangTheodore N Pappas
Jun 12, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shannon Melissa ChanAnthony Yuen Bun Teoh

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