Overactivation of the sodium-calcium exchanger and transient receptor potential in anesthesia-induced malignant hyperthermia

IUBMB Life
Peng ZhaoYun-Feng Cui

Abstract

Malignant hyperthermia is a pharmacogenetic disorder, which is an uncommon but frequently fatal intricacy of inhalation anesthesia in man. It causes a quick rise in body temperature to highly irreversible levels, which causes death in around three of four cases. The trigger anesthetics cause an anomalous, continued ascent in myoplasmic calcium levels. Possible mechanisms by which continuous release of sodium, calcium from skeletal muscle plasma membrane and sarcoplasmic reticulum stores respectively can produce the profound hyperthermia are discussed.

References

Jul 1, 1976·The Journal of Physiology·P F Baker, P A McNaughton
Jan 1, 1979·The Journal of General Physiology·R DiPolo
Jan 1, 1975·British Journal of Anaesthesia·I M Clarke, F R Ellis
Jul 24, 1975·The Journal of Membrane Biology·M P Blaustein, J M Russell
Jan 1, 1991·Annals of the New York Academy of Sciences·D C GadsbyM Nakao
Feb 1, 1986·Cell Calcium·J W Putney
Feb 1, 1971·Anesthesiology·R A Pollock, R L Watson
Jan 1, 1974·Journal of Supramolecular Structure·M P BlausteinP Weer
Jan 1, 1971·Anesthesia and Analgesia·M D LeighW Herbert
Feb 1, 1969·The Journal of Physiology·P F BakerR A Steinhardt
May 16, 1984·Biochimica Et Biophysica Acta·S Luciani
Jun 1, 1995·The Journal of Physiology·G FontanaM P Blaustein
May 8, 1995·Biochimica Et Biophysica Acta·W MelzerH C Lüttgau
Aug 1, 1994·Der Anaesthesist·A Urwyler, E Hartung
Oct 4, 1996·The Journal of Biological Chemistry·D A NicollK D Philipson
Apr 1, 1997·The American Journal of Physiology·B D QuednauK D Philipson
Jul 3, 1999·Physiological Reviews·M P Blaustein, W J Lederer
Apr 3, 2001·The Journal of Physiology·I SeckinY S Prakash
May 28, 2004·Molecular Biology and Evolution·Xinjiang Cai, Jonathan Lytton
May 24, 2005·Biochemical and Biophysical Research Communications·Hong XinKazuhiro Kohama
Feb 18, 2006·The Journal of Biological Chemistry·Eun Hui LeeP D Allen
Apr 26, 2007·Orphanet Journal of Rare Diseases·Henry RosenbergKathryn Stowell
Jun 21, 2007·Annual Review of Biochemistry·Kartik Venkatachalam, Craig Montell
Jan 22, 2008·British Journal of Pharmacology·Y M BahnasiD J Beech
Apr 22, 2008·Nature Reviews. Neuroscience·Nicholas P Franks
Jun 3, 2008·Journal of Molecular Biology·Agnieszka Galińska-RakoczyWilliam Lehman
Aug 12, 2008·Molecular Pharmacology·Paul M CornettGerard P Ahern
Feb 25, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marco DaineseFeliciano Protasi
Jun 11, 2009·British Journal of Anaesthesia·H C Hemmings
Oct 23, 2009·American Journal of Physiology. Cell Physiology·Nadège ZanouPhilippe Gailly
Nov 18, 2009·Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·Frank Schuster, Clemens R Müller-Reible
Feb 25, 2010·Pflügers Archiv : European journal of physiology·Matthew J Betzenhauser, Andrew R Marks
Jun 3, 2010·Frontiers in Bioscience (Landmark Edition)·Jose C Gonzalez-Cobos, Mohamed Trebak
Feb 4, 2011·Advances in Experimental Medicine and Biology·Heinrich Brinkmeier
Mar 23, 2011·Cold Spring Harbor Perspectives in Biology·Marisa Brini, Ernesto Carafoli
Aug 24, 2012·Nature Reviews. Molecular Cell Biology·Jonathan SoboloffDonald L Gill
Nov 20, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·José M EltitJosé R Lopez

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