Overactive Bladder Is Strongly Associated With Frailty in Older Individuals

Urology
Anne M SuskindEmily Finlayson

Abstract

To understand the relationship between age, frailty, and overactive bladder (OAB). This is a prospective study of individuals age ≥65 years presenting to an academic urology practice between December 2015 and July 2016. All patients had a Timed Up and Go Test (TUGT), a parsimonious measure of frailty, on intake, and were thereby categorized as fast (≤10 seconds), intermediate (11-14 seconds), and slow (≥15 seconds). The TUGT and other clinical data were abstracted from the electronic medical record using direct queries. Logistic regression was used to examine the relationship between frailty and the diagnosis of OAB, adjusting for age, gender, and race. Our cohort included 201 individuals with and 1162 individuals without OAB. Individuals with OAB had slower TUGTs (13.7 ± 7.9 seconds) than their non-OAB counterparts (10.9 ± 5.2 seconds), P <.0001, with 32.3% and 11.0% of OAB and non-OAB individuals being categorized as slow, or frail. In multivariable analysis, slower TUGT was a significant predictor of OAB (adjusted odds ratio: 3.0; 95% confidence interval: 2.0-4.8). Age was not independently associated with this diagnosis (P values >.05 for each age group). Patients with OAB are statistically significantly frailer than indivi...Continue Reading

References

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Feb 1, 2003·Urology·Paul AbramsUNKNOWN Standardisation Sub-Committee of the International Continence Society
Feb 27, 2003·Aging Clinical and Experimental Research·Maria NuotioMarja Jylhä
Sep 29, 2004·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Karin S CoyneTimothy L Hunt
Apr 5, 2007·BJU International·Adrian S WaggMark Vierhout
Jun 19, 2007·NeuroImage·Derek GriffithsNeil M Resnick
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Howard BergmanChristina Wolfson
Dec 29, 2009·Urology·Michael L GanzChris L Pashos
Mar 30, 2010·Journal of the American Geriatrics Society·Xiaowei SongKenneth Rockwood
Aug 14, 2012·Journal of the American Geriatrics Society·Rose M CollardRichard C Oude Voshaar
Sep 19, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·George M SavvaRose Anne Kenny
Apr 17, 2013·Physiological Reviews·Lori Birder, Karl-Erik Andersson
Aug 8, 2013·Obstetrics and Gynecology·Catherine A MatthewsFrancine Grodstein
Dec 11, 2013·International Urology and Nephrology·Pradeep TyagiMichael Chancellor
Apr 5, 2014·Neurourology and Urodynamics·Adrian WaggRuth Kirschner-Hermanns
Sep 10, 2015·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Barbara J ZarowitzJoseph G Ouslander

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Citations

Jul 19, 2017·Current Urology Reports·Anne M Suskind
Jul 25, 2019·Neurourology and Urodynamics·Hideaki ItoOsamu Yokoyama
Aug 23, 2019·Neurourology and Urodynamics·Kenji OmaeShunichi Fukuhara
Jul 10, 2019·Neurourology and Urodynamics·Anne M SuskindEmily Finlayson
Jun 3, 2020·Neurourology and Urodynamics·Sikai SongAnne M Suskind
Jun 20, 2020·Drugs & Aging·Christina Shaw, Adrian Wagg
Sep 19, 2019·International Urogynecology Journal·Julia K ShinnickVivian Sung
Aug 22, 2020·Journal of the American Geriatrics Society·Scott R BauerUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
Jun 25, 2019·The Journal of Nutrition, Health & Aging·S IdaK Murata
Nov 25, 2019·Aging Clinical and Experimental Research·Thomas F MonaghanJeffrey P Weiss
Jul 19, 2017·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Apul Goel
Sep 27, 2018·Advances in Therapy·Shelagh M SzaboAdrian S Wagg
Sep 12, 2018·Current Urology Reports·Toya S Pratt, Anne M Suskind
Apr 9, 2020·Annals of Physical and Rehabilitation Medicine·Thomas F MonaghanAlan J Wein
Oct 24, 2020·Drugs & Aging·Alyssa Gracely, Anne P Cameron
Dec 15, 2020·Current Bladder Dysfunction Reports·Caitlyn E Painter, Anne M Suskind
Jul 1, 2020·Urology·Benjamin M BruckerDiane K Newman
Oct 31, 2021·International Urogynecology Journal·Benoit SteenstrupMaxime Gilliaux

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