Overactive bladder syndrome and the potential role of prostaglandins and phosphodiesterases: an introduction

Nephro-urology Monthly
Mohammad S Rahnama'iPhilip E V van Kerrebroeck

Abstract

In this paper, a general introduction is given, presenting the overactive bladder syndrome (OAB) and its impact on the quality of life and economical burden in patients affected. Moreover, the anatomy, physiology and histology of the lower urinary tract are discussed, followed by a brief overview on the possible role of prostaglandin (PG) and phosphodiesterase type 5 (PDE5) in the urinary bladder. The current literature on the role and distribution of PGE2 and its receptors in the urinary bladder is discussed. In both animal models and in human studies, high levels of signaling molecules such as PG and cGMP have been implicated, in decreased functional bladder capacity and micturition volume, as well as in increased voiding contraction amplitude. As a consequence, inhibition of prostanoid production, the use of prostanoid receptor antagonists, or PDE inhibitors might be a rational way to treat patients with detrusor overactivity. Similarly, prostanoid receptor agonists, or agents that stimulate their production, might have a function in treating bladder underactivity.

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Citations

Oct 27, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Christian MoroRuss Chess-Williams
Dec 10, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Mohammad Sajjad Rahnama'i
Aug 20, 2020·Neurourology and Urodynamics·Maria Patricia RadaDan Mihu
Sep 2, 2020·World Journal of Urology·Abubakr H MossaLysanne Campeau
Jan 26, 2021·American Journal of Physiology. Renal Physiology·Péter József MolnárZoltán Benyó

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Methods Mentioned

BETA
transmission electron microscopy
urine storage

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