Overactive bladder syndrome treatment with ospemifene in menopausal patients with vulvovaginal atrophy: improvement of sexuality?

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
M C SchiaviP Benedetti Panici

Abstract

The aim of this study was to assess the effectiveness of ospemifene in the improvement of sexual function in postmenopausal women with vulvovaginal atrophy (VVA) affected by overactive bladder syndrome (OAB) or urge urinary incontinence (UUI). One hundred five postmenopausal patients with VVA affected by OAB and/or UUI were enrolled for the study. All patients received ospemifene 60 mg for 12 weeks. Clinical examination, 3-d voiding diary and the vaginal health index (VHI) were performed at baseline and at 12 weeks. Patients completed the OAB-Q SF, FSFI, FSDS, and SF-36 questionnaires. The patient's satisfaction was also calculated. After 12 weeks, the reduction of urinary symptoms was observed. The OAB-Q symptoms, OAB-Q (HRQL) score were (55.34 ± 13.54 vs. 23.22 ± 9.76; p < .0001) and (22.45 ± 9.78 vs. 70.56 ± 15.49; p < .0001), before and after treatment. SF-36 questionnaire showed a significant improvement (p < .0001). VHI score increased and the women who regularly practice sexual activity increased after treatment. The total FSFI score increased significantly and the FSDS score changed after 12 weeks (p < .0001). The PGI-I after 12 weeks showed a total success rate of 90.5%. Ospemifene is an effective potential therapy for...Continue Reading

References

Dec 1, 1995·Maturitas·G Bachmann
Jul 10, 2003·International Urogynecology Journal and Pelvic Floor Dysfunction·Anthony G ViscoUNKNOWN Pelvic Floor Disorders Network
Apr 24, 2009·Climacteric : the Journal of the International Menopause Society·J Calleja-Agius, M P Brincat
Feb 11, 2011·Journal of Public Health·Vanessa Burholt, Paul Nash
Apr 16, 2011·The Journal of Sexual Medicine·Karin S CoyneSteven A Kaplan
Jul 23, 2013·Neurourology and Urodynamics·Dudley RobinsonMark Vierhout
Aug 30, 2013·Climacteric : the Journal of the International Menopause Society·S R GoldsteinUNKNOWN Ospemifene Study Group
Dec 18, 2013·Menopause International·Dudley RobinsonLinda Cardozo
Jan 16, 2014·Climacteric : the Journal of the International Menopause Society·R E Nappi, S Palacios
Jul 16, 2014·International Urogynecology Journal·Catrina C CrispRachel N Pauls
Dec 5, 2015·Expert Opinion on Pharmacotherapy·JoAnn V Pinkerton, Risa Kagan
Aug 2, 2016·Expert Opinion on Drug Metabolism & Toxicology·Chiara BondiUmberto Leone Roberti Maggiore
Feb 23, 2017·Archives of Gynecology and Obstetrics·Michele Carlo SchiaviPierluigi Benedetti Panici
May 12, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Michele Carlo SchiaviPierluigi Benedetti Panici
Jun 1, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Stefania AlvisiMaria Cristina Meriggiola

❮ Previous
Next ❯

Citations

Apr 25, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lino Del Pup, Rafael Sánchez-Borrego
Sep 19, 2019·Expert Review of Endocrinology & Metabolism·David F ArcherIrwin Goldstein
Sep 25, 2020·F1000Research·George AraklitisLinda Cardozo
Mar 25, 2021·Gynécologie, Obstétrique, Fertilité & Sénologie·C HockéM Grellety-Cherbero
Nov 23, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·X Gamé, V Phé

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.