Overall and cause-specific premature mortality in epilepsy: A systematic review

Epilepsy & Behavior : E&B
Musa M WatilaJosemir W Sander

Abstract

We conducted a systematic review to ascertain the overall mortality and causes of premature mortality in epilepsy. We searched PubMed and Embase to identify relevant articles reporting mortality in epilepsy. An assessment of the methodological quality and overall quality of evidence of the identified studies was done using appropriate checklists. We extracted data from these studies reporting measures of overall and cause-specific mortality in epilepsy. Sixty-three articles from fifty-six cohorts met the eligibility criteria, thirty-three population- or community-based and twenty-three hospital- or institutional-based studies. The majority of studies are from high-income countries (HIC). These studies reported overall excess mortality for people with epilepsy, with wide variability reported for population- or community-based studies and from low- and middle-income countries (LMIC). Twenty-seven articles from twenty-three cohorts reported measures of mortality for cause-specific mortality in epilepsy. People with epilepsy from HIC and LMIC have a higher risk of dying from various causes compared with the general population. Those in LMIC, however, have a particularly high chance of dying from external causes such as drowning and...Continue Reading

Citations

Mar 9, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Mengjie WangJosemir W Sander
May 13, 2020·Epilepsia·Julia C M PottkämperMichel J A M van Putten
Jun 17, 2020·Pharmacological Reviews·Wolfgang LöscherAnnamaria Vezzani
Jun 2, 2020·Current Medical Research and Opinion·Boulenouar MesraouaAli A Asadi-Pooya
Nov 30, 2019·Frontiers in Public Health·Victor Patterson
Nov 29, 2020·Epilepsy & Behavior : E&B·Benzi M KlugerMark Spitz
Jan 21, 2021·Current Opinion in Neurology·Ali A Asadi-Pooya, Torbjörn Tomson
May 18, 2020·Seizure : the Journal of the British Epilepsy Association·Victor Patterson
Aug 7, 2021·Proceedings of the ACM on Human-computer Interaction·Aehong MinPatrick C Shih

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