Overall clinical and economic impact of non-alcoholic fatty liver disease.

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
Antoni Sicras-MainarSalvador Augustín

Abstract

to establish the clinical and economic consequences (resource utilization and healthcare costs) of non-alcoholic fatty liver in the setting of the usual clinical practice in Spain. an observational, retrospective study was performed based on a review of the medical records of adult patients ≥ 18 years of age who sought medical care from 2017 to 2018. Patients were categorized into two groups according to fibrosis stage (estimation method: FIB-4): a) F0-F2; and b) F3-F4 (advanced fibrosis). Follow-up lasted one year. Primary endpoints included comorbidity, concomitant medication, resource utilization and costs. Results were analyzed using a multivariate approach with p < 0.05. a total of 8,151 patients were recruited with a mean age of 61.1 years and 51.5 % were male. By group: a) mild fibrosis n = 7,127, 87.4 %; and b) advanced fibrosis n = 1,024, 12.6 % (6.8 % with liver cirrhosis). The most common comorbidities included 63 % dyslipidemia, 52 % obesity, 52 % hypertension and 35 % diabetes. The average number of drugs used was 2.1 per patient. Patients with advanced fibrosis (F3-F4) had a higher average number of concomitant medications (2.5 vs 2.1; p < 0.001) and a higher AST/ALT ratio (1.1 vs 0.8; p < 0.001). The average cost...Continue Reading

References

May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Aug 6, 2013·Hepatitis Monthly·Mohammad Ebrahim Ghamar ChehrehSeyed Moayed Alavian
Jul 16, 2014·Deutsches Ärzteblatt International·Johannes WeißAndreas Geier
Aug 4, 2015·PharmacoEconomics·Zobair M Younossi, Linda Henry
Oct 19, 2016·Medicina clínica·Rebeca Reyes-GarcíaPedro Mezquita-Raya
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Stefano Bellentani
Jul 29, 2017·Medicina clínica·Salvador AugustinUNKNOWN en nombre del grupo de trabajo sobre «Hígado graso no alcohólico» de la Societat Catalana de Digestologia
Oct 2, 2017·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Marc L BergerC Daniel Mullins
Oct 24, 2017·Annual Review of Pharmacology and Toxicology·Julia WattacherilArun Sanyal
Nov 4, 2017·Biochimie·Mengyue HuFabienne Foufelle
Feb 11, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Ana Ruth AraújoStefano Bellentani
Apr 11, 2018·Gastroenterología y hepatología·Rocío AllerManuel Romero-Gómez
May 19, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alina M AllenRozalina G McCoy
Jul 5, 2018·Expert Opinion on Drug Metabolism & Toxicology·Cene SkubicDamjana Rozman
Sep 5, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair YounossiMiriam B Vos
Jan 24, 2019·World Journal of Gastroenterology : WJG·Naoki TanakaEiji Tanaka
Jan 24, 2019·Laboratory animal research·Ji-Young ChaKyung-Hee Chun
Sep 29, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xu LiPujun Gao
Oct 2, 2019·International Journal of Chronic Obstructive Pulmonary Disease·Antoni Sicras MainarAfisi S Ismaila

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