Apr 20, 1983

Overall distribution of substance P-containing nerves in the wall of the cerebral arteries of the guinea pig and its origins

The Journal of Comparative Neurology
K YamamotoM Tohyama

Abstract

The overall distribution of substance P-like immunoreactivity (SPI) in the wall of the cerebral arteries and their origins were investigated in the guinea pig by using whole-mounts. Two types of SPI fibers were seen: one forming dense fiber bands and located among the periadventitial nerves, and the other forming a meshwork. The SPI fibers located in the periadventitial nerves often leave these nerves to form a meshwork of SPI fibers of varying density according to the diameter or location of the blood vessels. The present study suggests that: (1) SPI fibers located on the circle of Willis and its branches originate from SPI cells in the trigeminal ganglion; (2) SPI fibers of the rostral one-third of the basilar artery originate partly from trigeminal SPI cells; and (3) SPI fibers in the caudal two-thirds of the basilar artery originate exclusively from other SPI cells, apart from the trigeminal ganglion.

Mentioned in this Paper

TAC1
Immunofluorescence Assay
Immunofluorescence Microscopy
Structure of Vertebral Artery
Hypothalamic Substance P
Circle of Willis
Structure of Cerebral Artery
Cavia porcellus
Structure of Basilar Artery

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